Physician Data Query

Last uploaded: August 28, 2024
Preferred Name

naltrexone hydrochloride
Synonyms

Revia

Depade

(5alpha)-17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-one hydrochloride

Definitions

The hydrochloride salt of naltrexone, a noroxymorphone derivative with competitive opioid antagonistic activity. Naltrexone and its metabolite 6-beta-naltrexol reverse the effects of opioids by binding to various opioid receptors in the central nervous system CNS), including the mu-, kappa- and gamma-opioid receptors; opioid effects of analgesia, euphoria, sedation, respiratory depression, miosis, bradycardia, and physical dependence are inhibited. Naltrexone is longer-acting and more potent compared to naloxone. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C679" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C679" NCI Thesaurus)

ID

http://purl.bioontology.org/ontology/PDQ/CDR0000040818

altLabel

Revia

Depade

(5alpha)-17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-one hydrochloride

cui

C0355800

C0591842

C1602849

Date last modified

2008-04-07

definition

The hydrochloride salt of naltrexone, a noroxymorphone derivative with competitive opioid antagonistic activity. Naltrexone and its metabolite 6-beta-naltrexol reverse the effects of opioids by binding to various opioid receptors in the central nervous system CNS), including the mu-, kappa- and gamma-opioid receptors; opioid effects of analgesia, euphoria, sedation, respiratory depression, miosis, bradycardia, and physical dependence are inhibited. Naltrexone is longer-acting and more potent compared to naloxone. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C679" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C679" NCI Thesaurus)

Legacy PDQ ID

3847

LT

TRD

NCI ID

C679

notation

CDR0000040818

ORIG STY

Drug/agent

prefLabel

naltrexone hydrochloride

tui

T109

T121

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http://purl.bioontology.org/ontology/NDDF/001615 NDDF CUI
http://purl.bioontology.org/ontology/RXNORM/152092 RXNORM CUI
http://purl.bioontology.org/ontology/NDFRT/N0000179498 NDFRT CUI
http://purl.bioontology.org/ontology/SNOMEDCT/64191009 SNOMEDCT CUI
http://purl.bioontology.org/ontology/NDFRT/N0000146867 NDFRT CUI
http://purl.bioontology.org/ontology/VANDF/4018545 VANDF CUI
http://purl.bioontology.org/ontology/MESH/D009271 MESH CUI
http://purl.bioontology.org/ontology/RXNORM/105069 RXNORM CUI
http://purl.bioontology.org/ontology/MSHFRE/D009271 MSHFRE CUI
http://purl.bioontology.org/ontology/SNMI/C-60D21 SNMI CUI
http://purl.bioontology.org/ontology/SCTSPA/64191009 SCTSPA CUI
http://purl.bioontology.org/ontology/MESH/D009271 MESH CUI
http://purl.obolibrary.org/obo/CHEBI_134687 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_134687 CHEBI LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#31342 OCHV LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/64191009 SNOMEDCT LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0355800 OCHV LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146867 NDFRT LOOM
http://purl.bioontology.org/ontology/VANDF/4018545 VANDF LOOM
http://purl.obolibrary.org/obo/NCIT_C679 BERO LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C679 NCIT LOOM
http://www.co-ode.org/ontologies/galen#NaltrexoneHydrochloride GALEN LOOM
http://purl.bioontology.org/ontology/RXNORM/105069 RXNORM LOOM
http://purl.bioontology.org/ontology/SNMI/C-60D21 SNMI LOOM