Preferred Name | naltrexone hydrochloride | |
Synonyms |
Revia Depade (5alpha)-17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-one hydrochloride |
|
Definitions |
The hydrochloride salt of naltrexone, a noroxymorphone derivative with competitive opioid antagonistic activity. Naltrexone and its metabolite 6-beta-naltrexol reverse the effects of opioids by binding to various opioid receptors in the central nervous system CNS), including the mu-, kappa- and gamma-opioid receptors; opioid effects of analgesia, euphoria, sedation, respiratory depression, miosis, bradycardia, and physical dependence are inhibited. Naltrexone is longer-acting and more potent compared to naloxone. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C679" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C679" NCI Thesaurus) |
|
ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000040818 |
|
altLabel |
Revia Depade (5alpha)-17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-one hydrochloride |
|
cui |
C0355800 C0591842 C1602849 |
|
Date last modified |
2008-04-07 |
|
definition |
The hydrochloride salt of naltrexone, a noroxymorphone derivative with competitive opioid antagonistic activity. Naltrexone and its metabolite 6-beta-naltrexol reverse the effects of opioids by binding to various opioid receptors in the central nervous system CNS), including the mu-, kappa- and gamma-opioid receptors; opioid effects of analgesia, euphoria, sedation, respiratory depression, miosis, bradycardia, and physical dependence are inhibited. Naltrexone is longer-acting and more potent compared to naloxone. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C679" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C679" NCI Thesaurus) |
|
Legacy PDQ ID |
3847 |
|
LT |
TRD |
|
NCI ID |
C679 |
|
notation |
CDR0000040818 |
|
ORIG STY |
Drug/agent |
|
prefLabel |
naltrexone hydrochloride |
|
tui |
T109 T121 |