loading...| Preferred Name |
trifluoperazine hydrochloride |
|
| Synonyms |
Eskazine |
|
| Definitions |
The hydrochloride salt of trifluoperazine, a phenothiazine derivative and a dopamine, alpha-adrenergic, and anticholinergic antagonist with antipsychotic, anxiolytic, and antiemetic activities. Trifluoperazine blocks central dopamine receptors, which may prevent or mitigate delusions and hallucinations caused by an excess of dopamine; dopamine blockade in the chemoreceptor trigger zone (CTZ) may result in an antiemetic effect. This agent binds to central adrenergic receptors, which may result in anxiolytic effects.Trifluoperazine also functions as a calmodulin inhibitor, elevating cytosolic calcium. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C904" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C904" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000040446 |
|
| altLabel |
Eskazine Stelazine Jatroneural 10-(3-(4-methyl-1-piperazinyl)propyl)-2-(trifluoromethyl)-10H-phenothiazine dihydrochloride SKF 5019 Terfluzine |
|
| Component of |
http://purl.bioontology.org/ontology/PDQ/CDR0000041513 http://purl.bioontology.org/ontology/PDQ/CDR0000041523 |
|
| cui |
C1710485 C1710486 C1710483 C1710484 C0304381 C0733842 |
|
| Date last modified |
2008-04-07 |
|
| definition |
The hydrochloride salt of trifluoperazine, a phenothiazine derivative and a dopamine, alpha-adrenergic, and anticholinergic antagonist with antipsychotic, anxiolytic, and antiemetic activities. Trifluoperazine blocks central dopamine receptors, which may prevent or mitigate delusions and hallucinations caused by an excess of dopamine; dopamine blockade in the chemoreceptor trigger zone (CTZ) may result in an antiemetic effect. This agent binds to central adrenergic receptors, which may result in anxiolytic effects.Trifluoperazine also functions as a calmodulin inhibitor, elevating cytosolic calcium. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C904" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C904" NCI Thesaurus) |
|
| Legacy PDQ ID |
3318 |
|
| LT |
TRD |
|
| NCI ID |
C904 |
|
| notation |
CDR0000040446 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
trifluoperazine hydrochloride |
|
| tui |
T109 T121 |