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Physician Data Query
Last uploaded:
August 28, 2024
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| Preferred Name | pentamidine | |
| Synonyms |
Aerosolized Pentamadine |
|
| Definitions |
A synthetic derivative of amidine with antiprotozoal and antifungal activities. Although the precise mode of action of pentamidine is unclear, it appears to interact directly with the pathogen genome by binding to AT-rich regions of duplex DNA and the minor groove of DNA, thereby interfering with DNA replication. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C731" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C731" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000040324 |
|
| altLabel |
Aerosolized Pentamadine
|
|
| CAS Registry |
100-33-4
|
|
| Component of | ||
| cui |
C0030863
|
|
| Date last modified |
2006-12-27
|
|
| definition |
A synthetic derivative of amidine with antiprotozoal and antifungal activities. Although the precise mode of action of pentamidine is unclear, it appears to interact directly with the pathogen genome by binding to AT-rich regions of duplex DNA and the minor groove of DNA, thereby interfering with DNA replication. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C731" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C731" NCI Thesaurus)
|
|
| Legacy PDQ ID |
3166
|
|
| NCI ID |
C731
|
|
| notation |
CDR0000040324
|
|
| NSC Code |
9921
|
|
| ORIG STY |
Drug/agent
|
|
| prefLabel |
pentamidine
|
|
| tui |
T109 T121
|
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