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Physician Data Query
| Preferred Name | dapsone | |
| Synonyms |
sulfona-mae 4,4'-sulfonylbisbenzeneamine DADPS croysulfone Undolac dumitone Avlosulfon DDS novophone bis(4-aminophenyl)sulfone 1358F sulphadione 4,4'-sulfonylbisbenzamine Eporal 4,4'-sulfonyldianiline Aczone Disulone diphenasone |
|
| Definitions |
A synthetic derivative of diamino-sulfone with anti-inflammatory and anti-bacterial properties. As a structural analog of p-aminobenzoic acid (PABA), dapsone inhibits dihydropteroate synthase (DHPS), an enzyme important in folate synthesis, resulting in a depletion of the folate pool and a reduction in the amount of thymidylate available for DNA synthesis. Although the exact mechanism through which dapsone exerts its anti-inflammatory activity has yet to be fully elucidated, this agent interferes with the activation and oxidative damage of myeloperoxidase in neutrophils and inhibits the integrin-mediated adherence and chemotaxis of neutrophils. Dapsone's anti-inflammatory activities may contribute to the effects seen upon topical administration. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C415" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C415" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000040323 |
|
| altLabel |
sulfona-mae 4,4'-sulfonylbisbenzeneamine DADPS croysulfone Undolac dumitone Avlosulfon DDS novophone bis(4-aminophenyl)sulfone 1358F sulphadione 4,4'-sulfonylbisbenzamine Eporal 4,4'-sulfonyldianiline Aczone Disulone diphenasone
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| CAS Registry |
80-08-0
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| Component of | ||
| cui |
C1527112 C1511722 C0729116 C1511721 C0010980 C1652085 C1511723
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| Date last modified |
2017-04-05
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|
| definition |
A synthetic derivative of diamino-sulfone with anti-inflammatory and anti-bacterial properties. As a structural analog of p-aminobenzoic acid (PABA), dapsone inhibits dihydropteroate synthase (DHPS), an enzyme important in folate synthesis, resulting in a depletion of the folate pool and a reduction in the amount of thymidylate available for DNA synthesis. Although the exact mechanism through which dapsone exerts its anti-inflammatory activity has yet to be fully elucidated, this agent interferes with the activation and oxidative damage of myeloperoxidase in neutrophils and inhibits the integrin-mediated adherence and chemotaxis of neutrophils. Dapsone's anti-inflammatory activities may contribute to the effects seen upon topical administration. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C415" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C415" NCI Thesaurus)
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| Legacy PDQ ID |
3165
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|
| LT |
TRD
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| NCI ID |
C415
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|
| notation |
CDR0000040323
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| NSC Code |
6091
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| ORIG STY |
Drug/agent
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| prefLabel |
dapsone
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|
| tui |
T109 T121
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