Physician Data Query

Last uploaded: August 27, 2019
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Preferred Name

probenecid
Synonyms

PROB

Benemid

SK-Probenecid
Definitions

A benzoic acid derivative with antihyperuricemic property. Probenecid competitively inhibits the active reabsorption of urate at the proximal tubule in the kidney thereby increasing urinary excretion of uric acid and lowering serum urate concentrations. This prevents urate deposition and promotes resolution of existing urate deposits. In addition, probenecid modulates the transport of organic acids and acidic drugs at the proximal and distal renal tubule, thereby increasing the drug serum concentration. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C772" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C772" NCI Thesaurus)
ID

http://purl.bioontology.org/ontology/PDQ/CDR0000040223
altLabel

PROB

Benemid

SK-Probenecid
CAS Registry

57-66-9
Component of

http://purl.bioontology.org/ontology/PDQ/CDR0000038426
cui

C0729110

C0591159

C0033209
definition

A benzoic acid derivative with antihyperuricemic property. Probenecid competitively inhibits the active reabsorption of urate at the proximal tubule in the kidney thereby increasing urinary excretion of uric acid and lowering serum urate concentrations. This prevents urate deposition and promotes resolution of existing urate deposits. In addition, probenecid modulates the transport of organic acids and acidic drugs at the proximal and distal renal tubule, thereby increasing the drug serum concentration. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C772" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C772" NCI Thesaurus)
Legacy PDQ ID

3033
LT

TRD
NCI ID

C772
notation

CDR0000040223
NSC Code

18786
ORIG STY

Drug/agent
prefLabel

probenecid
tui

T109

T121
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Mapping To Ontology Source
http://purl.bioontology.org/ontology/RCD/x02VG RCD CUI
http://purl.bioontology.org/ontology/CSP/2840-3387 CRISP CUI
http://purl.bioontology.org/ontology/MESH/D011339 MESH CUI
http://purl.bioontology.org/ontology/LNC/LP16260-9 LOINC CUI
http://purl.bioontology.org/ontology/RXNORM/8698 RXNORM CUI
http://purl.bioontology.org/ontology/SCTSPA/387365004 SCTSPA CUI
http://purl.bioontology.org/ontology/SNMI/C-72610 SNMI CUI
http://purl.bioontology.org/ontology/NDDF/002321 NDDF CUI
http://purl.bioontology.org/ontology/LNC/MTHU007603 LOINC CUI
http://purl.bioontology.org/ontology/NDFRT/N0000146225 NDFRT CUI
http://purl.bioontology.org/ontology/SCTSPA/66094001 SCTSPA CUI
http://purl.bioontology.org/ontology/SNOMEDCT/66094001 SNOMEDCT CUI
http://purl.bioontology.org/ontology/VANDF/4017872 VANDF CUI
http://purl.bioontology.org/ontology/SNOMEDCT/387365004 SNOMEDCT CUI
http://purl.bioontology.org/ontology/CSP/2840-3387 CRISP CUI
http://purl.bioontology.org/ontology/RCD/j63.. RCD CUI
http://purl.bioontology.org/ontology/MSHFRE/D011339 MSHFRE CUI
http://purl.bioontology.org/ontology/MESH/D011339 MESH CUI
http://purl.bioontology.org/ontology/NDFRT/N0000005795 NDFRT CUI
http://purl.bioontology.org/ontology/ATC/M04AB01 ATC CUI
http://purl.bioontology.org/ontology/CSP/2840-3387 CRISP LOOM
http://purl.obolibrary.org/obo/CHEBI_8426 DRON LOOM
http://purl.obolibrary.org/obo/XCO_0001206 XCO LOOM
http://purl.obolibrary.org/obo/CHEBI_8426 CHEBI LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0033209 OCHV LOOM
http://purl.obolibrary.org/obo/OMIT_0012295 OMIT LOOM
http://purl.bioontology.org/ontology/LNC/LP16260-9 LOINC LOOM
http://purl.bioontology.org/ontology/RXNORM/8698 RXNORM LOOM
http://www.co-ode.org/ontologies/galen#Probenecid GALEN LOOM
http://stirdf.jst.go.jp/id/200907013057451135 IOBC LOOM
http://purl.bioontology.org/ontology/SNMI/C-72610 SNMI LOOM
http://purl.obolibrary.org/obo/DRON_00014428 ODNAE LOOM
http://purl.obolibrary.org/obo/NCIT_C772 BERO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.065.884.625 RH-MESH LOOM
http://www.phoc.org.cn/pmo/class/PMO_00015959 PMAPP-PMO LOOM
http://purl.bioontology.org/ontology/NDDF/002321 NDDF LOOM
http://purl.jp/bio/4/id/200906015026554512 IOBC LOOM
http://purl.bioontology.org/ontology/LNC/MTHU007603 LOINC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#10133 OCHV LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146225 NDFRT LOOM
http://ontology.apa.org/apaonto/termsonlyOUT%20(5).owl#Probenecid APAONTO LOOM
http://purl.bioontology.org/ontology/VANDF/4017872 VANDF LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C772 NCIT LOOM
http://www.drugbank.ca/drugs/DB01032 FTC LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387365004 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/CSP/2840-3387 CRISP LOOM
http://purl.bioontology.org/ontology/RCD/j63.. RCD LOOM
https://go.drugbank.com/drugs/DB01032 MDM LOOM
http://purl.bioontology.org/ontology/MESH/D011339 MESH LOOM
http://purl.obolibrary.org/obo/MESH_D011339 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_8426 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_8426 FIDEO LOOM
http://purl.obolibrary.org/obo/CHEBI_8426 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_8426 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_8426 DDSS LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D011339 RH-MESH LOOM
http://www.bioassayontology.org/bao#BAO_0000998 BAO LOOM
http://purl.bioontology.org/ontology/ATC/M04AB01 ATC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.886.590.700.625 RH-MESH LOOM