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Last uploaded: August 28, 2024

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Preferred Name	zidovudine
Synonyms	azidothymidine ZDV AZT Aztec Retrovir 3'-azido-3'-deoxythymidine BW-A509U
Definitions	A synthetic dideoxynucleoside. After intracellular phosphorylation to its active metabolite, zidovudine inhibits DNA polymerase, resulting in the inhibition of DNA replication and cell death. This agent also decreases levels of available pyrimidines. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C947" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C947" NCI Thesaurus)
ID	http://purl.bioontology.org/ontology/PDQ/CDR0000040121
altLabel	azidothymidine ZDV AZT Aztec Retrovir 3'-azido-3'-deoxythymidine BW-A509U
CAS Registry	30516-87-1
Component of	http://purl.bioontology.org/ontology/PDQ/CDR0000039433 http://purl.bioontology.org/ontology/PDQ/CDR0000400148 http://purl.bioontology.org/ontology/PDQ/CDR0000040315 http://purl.bioontology.org/ontology/PDQ/CDR0000041787 http://purl.bioontology.org/ontology/PDQ/CDR0000041173 http://purl.bioontology.org/ontology/PDQ/CDR0000043687 http://purl.bioontology.org/ontology/PDQ/CDR0000041171 http://purl.bioontology.org/ontology/PDQ/CDR0000039113 http://purl.bioontology.org/ontology/PDQ/CDR0000041642 http://purl.bioontology.org/ontology/PDQ/CDR0000041480 http://purl.bioontology.org/ontology/PDQ/CDR0000041685 http://purl.bioontology.org/ontology/PDQ/CDR0000038709 http://purl.bioontology.org/ontology/PDQ/CDR0000041643 http://purl.bioontology.org/ontology/PDQ/CDR0000400149 http://purl.bioontology.org/ontology/PDQ/CDR0000038927 http://purl.bioontology.org/ontology/PDQ/CDR0000039394 http://purl.bioontology.org/ontology/PDQ/CDR0000041048 http://purl.bioontology.org/ontology/PDQ/CDR0000041860 http://purl.bioontology.org/ontology/PDQ/CDR0000039112 http://purl.bioontology.org/ontology/PDQ/CDR0000041826 http://purl.bioontology.org/ontology/PDQ/CDR0000038981 http://purl.bioontology.org/ontology/PDQ/CDR0000039398 http://purl.bioontology.org/ontology/PDQ/CDR0000041321 http://purl.bioontology.org/ontology/PDQ/CDR0000038096
cui	C0043474 C0701305 C1524114 C0699576
Date last modified	2006-09-28
definition	A synthetic dideoxynucleoside. After intracellular phosphorylation to its active metabolite, zidovudine inhibits DNA polymerase, resulting in the inhibition of DNA replication and cell death. This agent also decreases levels of available pyrimidines. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C947" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C947" NCI Thesaurus)
IND Code	34545 35782 26635 33134 30858
Legacy PDQ ID	2885
LT	TRD
NCI ID	C947
notation	CDR0000040121
NSC Code	602670
ORIG STY	Drug/agent
prefLabel	zidovudine
tui	T114 T121

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Mapping To	Ontology	Source
http://purl.bioontology.org/ontology/RXNORM/11413	RXNORM	CUI
http://purl.bioontology.org/ontology/MESH/D015215	MESH	CUI
http://purl.bioontology.org/ontology/RCD/x02pS	RCD	CUI
http://purl.bioontology.org/ontology/RCD/ei5..	RCD	CUI
http://purl.bioontology.org/ontology/MESH/D015215	MESH	CUI
http://purl.bioontology.org/ontology/LNC/LP16744-2	LOINC	CUI
http://purl.bioontology.org/ontology/LNC/MTHU013874	LOINC	CUI
http://purl.bioontology.org/ontology/SNOMEDCT/27479000	SNOMEDCT	CUI
http://purl.bioontology.org/ontology/SCTSPA/387151007	SCTSPA	CUI
http://purl.bioontology.org/ontology/NDFRT/N0000147622	NDFRT	CUI
http://purl.bioontology.org/ontology/ATC/J05AF01	ATC	CUI
http://purl.bioontology.org/ontology/SNMI/C-55B60	SNMI	CUI
http://purl.bioontology.org/ontology/CSP/2109-4800	CRISP	CUI
http://purl.bioontology.org/ontology/VANDF/4019502	VANDF	CUI
http://purl.bioontology.org/ontology/SNOMEDCT/387151007	SNOMEDCT	CUI
http://purl.bioontology.org/ontology/NDDF/003019	NDDF	CUI
http://purl.bioontology.org/ontology/MSHFRE/D015215	MSHFRE	CUI
http://purl.bioontology.org/ontology/SCTSPA/27479000	SCTSPA	CUI
http://purl.bioontology.org/ontology/NDFRT/N0000006933	NDFRT	CUI
http://purl.bioontology.org/ontology/MSHFRE/D015215	MSHFRE	CUI
http://purl.bioontology.org/ontology/MESH/D015215	MESH	CUI
http://purl.bioontology.org/ontology/RXNORM/202791	RXNORM	CUI
http://purl.bioontology.org/ontology/CSP/2109-4800	CRISP	CUI
http://purl.bioontology.org/ontology/RXNORM/11413	RXNORM	LOOM
http://purl.obolibrary.org/obo/OMIT_0016006	OMIT	LOOM
http://stirdf.jst.go.jp/id/200907007102849056	IOBC	LOOM
http://purl.jp/bio/4/id/200906043535188812	IOBC	LOOM
http://purl.obolibrary.org/obo/ARO_3007687	ARO	LOOM
http://purl.obolibrary.org/obo/NCIT_C947	BERO	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00018396	PMAPP-PMO	LOOM
http://purl.obolibrary.org/obo/CHEBI_10110	DRON	LOOM
http://purl.obolibrary.org/obo/CHEBI_10110	PDRO	LOOM
http://purl.obolibrary.org/obo/CHEBI_10110	HOIP	LOOM
http://purl.obolibrary.org/obo/CHEBI_10110	DINTO	LOOM
http://purl.obolibrary.org/obo/CHEBI_10110	BAO	LOOM
http://purl.obolibrary.org/obo/CHEBI_10110	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_10110	DDSS	LOOM
http://purl.obolibrary.org/obo/CHEBI_10110	TXPO	LOOM
http://purl.obolibrary.org/obo/CHEBI_10110	BIOMODELS	LOOM
http://purl.obolibrary.org/obo/CHEBI_10110	GSSO	LOOM
http://purl.obolibrary.org/obo/CHEBI_10110	CHEBI	LOOM
http://purl.obolibrary.org/obo/CHEBI_10110	DRON	LOOM
http://purl.obolibrary.org/obo/CHEBI_10110	ODNAE	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D13.570.230.500.950	RH-MESH	LOOM
http://www.drugbank.ca/drugs/DB00495	FTC	LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000147622	ODAE	LOOM
http://purl.bioontology.org/ontology/MESH/D015215	MESH	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D13.570.230.855.950	RH-MESH	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C947	NCIT	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D015215	RH-MESH	LOOM
http://purl.bioontology.org/ontology/LNC/LP16744-2	LOINC	LOOM
http://purl.bioontology.org/ontology/LNC/MTHU013874	LOINC	LOOM
http://www.co-ode.org/ontologies/galen#Zidovudine	GALEN	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#13273	OCHV	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D13.570.685.705.950	RH-MESH	LOOM
http://www.semanticweb.org/zchero/ontologies/2023/11/SepsisOntology#Zidovudine	SEPON	LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147622	NDFRT	LOOM
http://purl.bioontology.org/ontology/ATC/J05AF01	ATC	LOOM
http://purl.obolibrary.org/obo/MESH_D015215	BERO	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.383.742.680.705.950	RH-MESH	LOOM
https://go.drugbank.com/drugs/DB00495	MDM	LOOM
http://purl.bioontology.org/ontology/SNMI/C-55B60	SNMI	LOOM
http://purl.bioontology.org/ontology/CSP/2109-4800	CRISP	LOOM
http://purl.bioontology.org/ontology/VANDF/4019502	VANDF	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387151007	SNOMEDCT	LOOM
http://ontology.apa.org/apaonto/termsonlyOUT%20(5).owl#Zidovudine	APAONTO	LOOM