loading...| Preferred Name | chronic myelogenous leukemia, BCR-ABL1 positive | |
| Synonyms |
Ph1-positive chronic granulocytic leukemia Philadelphia chromosome-positive CML Philadelphia chromosome positive chronic myelogenous leukemia myelocytic leukemia, chronic, Philadelphia chromosome-positive myelogenous leukemia, chronic, Philadelphia chromosome-positive Philadelphia chromosome positive chronic granulocytic leukemia Ph1 chromosome-positive chronic myelocytic leukemia Philadelphia chromosome-positive chronic myeloid leukemia Ph1-positive chronic myelogenous leukemia Ph1 chromosome-positive chronic myeloid leukemia granulocytic leukemia, chronic, Philadelphia chromosome-positive chronic myeloid leukemia t(9;22) (q34;q11), BCR/ABL positive Ph1 chromosome-positive chronic myelogenous leukemia chronic myelocytic leukemia, Philadelphia chromosome-positive Ph1-positive CML Philadelphia chromosome-positive chronic myelocytic leukemia CML, Philadelphia chromosome-positive CGL, Philadelphia chromosome-positive chronic myelogenous leukemia, Philadelphia chromosome-positive chronic granulocytic leukemia, Philadelphia chromosome-positive |
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| Definitions |
A chronic myeloproliferative neoplasm characterized by the expression of the BCR-ABL1 fusion gene. It presents with neutrophilic leukocytosis. It can appear at any age, but it mostly affects middle aged and older individuals. Patients usually present with fatigue, weight loss, anemia, night sweats, and splenomegaly. If untreated, it follows a biphasic or triphasic natural course; an initial indolent chronic phase which is followed by an accelerated phase, a blast phase, or both. Allogeneic stem cell transplantation and imatinib therapy delay disease progression and prolong overall survival. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C9128" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C9128" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000039829 |
|
| altLabel |
Ph1-positive chronic granulocytic leukemia Philadelphia chromosome-positive CML Philadelphia chromosome positive chronic myelogenous leukemia myelocytic leukemia, chronic, Philadelphia chromosome-positive myelogenous leukemia, chronic, Philadelphia chromosome-positive Philadelphia chromosome positive chronic granulocytic leukemia Ph1 chromosome-positive chronic myelocytic leukemia Philadelphia chromosome-positive chronic myeloid leukemia Ph1-positive chronic myelogenous leukemia Ph1 chromosome-positive chronic myeloid leukemia granulocytic leukemia, chronic, Philadelphia chromosome-positive chronic myeloid leukemia t(9;22) (q34;q11), BCR/ABL positive Ph1 chromosome-positive chronic myelogenous leukemia chronic myelocytic leukemia, Philadelphia chromosome-positive Ph1-positive CML Philadelphia chromosome-positive chronic myelocytic leukemia CML, Philadelphia chromosome-positive CGL, Philadelphia chromosome-positive chronic myelogenous leukemia, Philadelphia chromosome-positive chronic granulocytic leukemia, Philadelphia chromosome-positive |
|
| cui |
C0279543 |
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| Date last modified |
2011-06-03 |
|
| definition |
A chronic myeloproliferative neoplasm characterized by the expression of the BCR-ABL1 fusion gene. It presents with neutrophilic leukocytosis. It can appear at any age, but it mostly affects middle aged and older individuals. Patients usually present with fatigue, weight loss, anemia, night sweats, and splenomegaly. If untreated, it follows a biphasic or triphasic natural course; an initial indolent chronic phase which is followed by an accelerated phase, a blast phase, or both. Allogeneic stem cell transplantation and imatinib therapy delay disease progression and prolong overall survival. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C9128" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C9128" NCI Thesaurus) |
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| Legacy PDQ ID |
2508 |
|
| NCI ID |
C9128 |
|
| notation |
CDR0000039829 |
|
| ORIG STY |
Neoplasm diagnosis |
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| prefLabel |
chronic myelogenous leukemia, BCR-ABL1 positive |
|
| tui |
T191 |
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| subClassOf |