Link to this page
Physician Data Query
| Preferred Name | alprazolam | |
| Synonyms |
Apo-Alpzar Nu-Alpraz Xanax |
|
| Definitions |
A triazolobenzodiazepine agent with anxiolytic, sedative-hypnotic and anticonvulsant activities. Alprazolam binds to a specific site distinct from the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) binding site on the benzodiazepine-GABA-A-chloride ionophore receptor complex located in the limbic, thalamic and hypothalamic regions of the central nervous system (CNS). This binding causes an allosteric modification of the receptor and enhances the affinity of GABA to the receptor leading to an increase in the frequency of chloride-channel opening events. This leads to an increase in chloride ion conductance, neuronal hyperpolarization, inhibition of the action potential and leads to a decrease in neuronal excitability. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C227" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C227" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000039659 |
|
| altLabel |
Apo-Alpzar Nu-Alpraz Xanax
|
|
| CAS Registry |
28981-97-7
|
|
| cui |
C0002333 C1515925 C1257671 C0699034
|
|
| definition |
A triazolobenzodiazepine agent with anxiolytic, sedative-hypnotic and anticonvulsant activities. Alprazolam binds to a specific site distinct from the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) binding site on the benzodiazepine-GABA-A-chloride ionophore receptor complex located in the limbic, thalamic and hypothalamic regions of the central nervous system (CNS). This binding causes an allosteric modification of the receptor and enhances the affinity of GABA to the receptor leading to an increase in the frequency of chloride-channel opening events. This leads to an increase in chloride ion conductance, neuronal hyperpolarization, inhibition of the action potential and leads to a decrease in neuronal excitability. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C227" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C227" NCI Thesaurus)
|
|
| Legacy PDQ ID |
2314
|
|
| LT |
TRD
|
|
| NCI ID |
C227
|
|
| notation |
CDR0000039659
|
|
| ORIG STY |
Drug/agent
|
|
| prefLabel |
alprazolam
|
|
| tui |
T109 T121
|
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |