Xylocaine

Xylocitin

Xylotox

2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide monohydrochloride

The hydrochloride salt from of lidocaine, an aminoethylamide and a prototypical member of the amide class anesthetics. Lidocaine interacts with voltage-gated Na+ channels in the nerve cell membrane and blocks the transient increase in permeability of excitable membranes to Na+. This prevents the generation and conduction of nerve impulses and produces a reversible loss of sensation. Lidocaine hydrochloride also exhibits class IB antiarrhythmic effects. The agent decreases the flow of sodium ions into myocardial tissue, especially on the Purkinje network, during phase 0 of the action potential, thereby decreasing depolarization, automaticity and excitability. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C48000" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C48000" NCI Thesaurus)

http://purl.bioontology.org/ontology/PDQ/CDR0000039607