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Physician Data Query
| Preferred Name | metronidazole hydrochloride | |
| Synonyms |
Flagyl SC 32642 Satric |
|
| Definitions |
The hydrochloride salt of a synthetic nitroimidazole derivative with antiprotozoal and antibacterial activities. Although its mechanism of action is not fully elucidated, un-ionized metronidazole is readily taken up by obligate anaerobic organisms and is subsequently reduced by low-redox potential electron-transport proteins to an active, intermediate product. Reduced metronidazole causes DNA strand breaks, thereby inhibiting DNA synthesis and bacterial cell growth. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C48005" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C48005" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000039503 |
|
| altLabel |
Flagyl SC 32642 Satric
|
|
| CAS Registry |
69198-10-3
|
|
| Component of |
http://purl.bioontology.org/ontology/PDQ/CDR0000041457 http://purl.bioontology.org/ontology/PDQ/CDR0000041458 http://purl.bioontology.org/ontology/PDQ/CDR0000041459 http://purl.bioontology.org/ontology/PDQ/CDR0000041456 http://purl.bioontology.org/ontology/PDQ/CDR0000041455 |
|
| cui |
C2919050 C0282239 C0699684 C0699678
|
|
| Date last modified |
2017-11-02
|
|
| definition |
The hydrochloride salt of a synthetic nitroimidazole derivative with antiprotozoal and antibacterial activities. Although its mechanism of action is not fully elucidated, un-ionized metronidazole is readily taken up by obligate anaerobic organisms and is subsequently reduced by low-redox potential electron-transport proteins to an active, intermediate product. Reduced metronidazole causes DNA strand breaks, thereby inhibiting DNA synthesis and bacterial cell growth. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C48005" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C48005" NCI Thesaurus)
|
|
| Legacy PDQ ID |
2137
|
|
| LT |
TRD
|
|
| NCI ID |
C48005
|
|
| notation |
CDR0000039503
|
|
| ORIG STY |
Drug/agent
|
|
| prefLabel |
metronidazole hydrochloride
|
|
| tui |
T109 T121
|
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