methadone hydrochloride

Adanon

The hydrochloride salt of methadone, a synthetic opioid with analgesic activity. Similar to morphine and other morphine-like agents, methadone mimics the actions of endogenous peptides at CNS opioid receptors, primarily the mu-receptor, resulting in characteristic morphine-like effects including analgesia, euphoria, sedation, respiratory depression, miosis, bradycardia and physical dependence. Because of the prolonged half-life of merthadone compared to other morphine-like agents such as heroin, the onset of opiate withdrawal symptoms is slower, the duration of opiate withdrawal is prolonged, and opiate wihdrawal symptoms are less severe. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C638" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C638" NCI Thesaurus)

http://purl.bioontology.org/ontology/PDQ/CDR0000039498

Adanon

Methadose

Dolophine

Althose

C0592779

C0699057

C0699059

C0699058

C0721688

2008-04-03

The hydrochloride salt of methadone, a synthetic opioid with analgesic activity. Similar to morphine and other morphine-like agents, methadone mimics the actions of endogenous peptides at CNS opioid receptors, primarily the mu-receptor, resulting in characteristic morphine-like effects including analgesia, euphoria, sedation, respiratory depression, miosis, bradycardia and physical dependence. Because of the prolonged half-life of merthadone compared to other morphine-like agents such as heroin, the onset of opiate withdrawal symptoms is slower, the duration of opiate withdrawal is prolonged, and opiate wihdrawal symptoms are less severe. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C638" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C638" NCI Thesaurus)

2131

TRD

C638

CDR0000039498

Drug/agent

methadone hydrochloride

T109

T121