Link to this page
Physician Data Query
| Preferred Name | ketoconazole | |
| Synonyms |
R-41400 Nizoral Fungarest cis-1-acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazole-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine Orifungal M Ketoisdin Xolegel Fungoral KCZ Panfungol Ketoderm |
|
| Definitions |
A synthetic derivative of phenylpiperazine with broad antifungal properties and potential antineoplastic activity. Ketoconazole inhibits sterol 14-a-dimethylase, a microsomal cytochrome P450-dependent enzyme, thereby disrupting synthesis of ergosterol, an important component of the fungal cell wall. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C605" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C605" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000039488 |
|
| altLabel |
R-41400 Nizoral Fungarest cis-1-acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazole-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine Orifungal M Ketoisdin Xolegel Fungoral KCZ Panfungol Ketoderm
|
|
| CAS Registry |
65277-42-1
|
|
| Component of |
http://purl.bioontology.org/ontology/PDQ/CDR0000363904 http://purl.bioontology.org/ontology/PDQ/CDR0000042809 http://purl.bioontology.org/ontology/PDQ/CDR0000042292 http://purl.bioontology.org/ontology/PDQ/CDR0000363905 http://purl.bioontology.org/ontology/PDQ/CDR0000043415 http://purl.bioontology.org/ontology/PDQ/CDR0000041521 http://purl.bioontology.org/ontology/PDQ/CDR0000041522 http://purl.bioontology.org/ontology/PDQ/CDR0000042201 http://purl.bioontology.org/ontology/PDQ/CDR0000041457 http://purl.bioontology.org/ontology/PDQ/CDR0000038119 http://purl.bioontology.org/ontology/PDQ/CDR0000041458 http://purl.bioontology.org/ontology/PDQ/CDR0000038668 http://purl.bioontology.org/ontology/PDQ/CDR0000394171 http://purl.bioontology.org/ontology/PDQ/CDR0000041459 http://purl.bioontology.org/ontology/PDQ/CDR0000041456 http://purl.bioontology.org/ontology/PDQ/CDR0000041460 |
|
| cui |
C1739451 C1517669 C1517666 C1517671 C1517668 C1517667 C0022625 C0699439 C0701304 C1517670
|
|
| Date last modified |
2008-10-06
|
|
| definition |
A synthetic derivative of phenylpiperazine with broad antifungal properties and potential antineoplastic activity. Ketoconazole inhibits sterol 14-a-dimethylase, a microsomal cytochrome P450-dependent enzyme, thereby disrupting synthesis of ergosterol, an important component of the fungal cell wall. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C605" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C605" NCI Thesaurus)
|
|
| Legacy PDQ ID |
2121
|
|
| LT |
TRD
|
|
| NCI ID |
C605
|
|
| notation |
CDR0000039488
|
|
| NSC Code |
317629
|
|
| ORIG STY |
Drug/agent
|
|
| prefLabel |
ketoconazole
|
|
| tui |
T109 T195 T121
|
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |