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| Preferred Name | omacetaxine mepesuccinate | |
| Synonyms |
HHT cephalotaxine, 4-methyl 2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate (Ester) cephalotaxine, 4-methyl 2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate (ester), [3(R)]- (9CI) homoharringtonine 1-[(1S,3aR,14bS)-2-methoxy-1,5,6,8,9,14b-hexahydro-4H- cyclopenta[a][1,3]dioxolo[4,5-h]pyrrolo[2,1-b][3]benzazepin-1-yl] 4-methyl (2R)-2- hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate CGX-635 Synribo |
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| Definitions |
A semisynthetic formulation of the cytotoxic plant alkaloid homoharringtonine isolated from the evergreen tree Cephalotaxus with potential antineoplastic activity. Omacetaxine mepesuccinate binds to the 80S ribosome in eukaryotic cells and inhibits protein synthesis by interfering with chain elongation. This agent also induces differentiation and apoptosis in some cancer cell types. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1127" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1127" NCI Thesaurus) |
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| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000039476 |
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| altLabel |
HHT cephalotaxine, 4-methyl 2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate (Ester) cephalotaxine, 4-methyl 2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate (ester), [3(R)]- (9CI) homoharringtonine 1-[(1S,3aR,14bS)-2-methoxy-1,5,6,8,9,14b-hexahydro-4H- cyclopenta[a][1,3]dioxolo[4,5-h]pyrrolo[2,1-b][3]benzazepin-1-yl] 4-methyl (2R)-2- hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate CGX-635 Synribo
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| CAS Registry |
26833-87-4
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| Component of |
http://purl.bioontology.org/ontology/PDQ/CDR0000042027 http://purl.bioontology.org/ontology/PDQ/CDR0000042997 |
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| cui |
C3504807 C0062941 C2709279
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| Date last modified |
2012-10-30
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|
| definition |
A semisynthetic formulation of the cytotoxic plant alkaloid homoharringtonine isolated from the evergreen tree Cephalotaxus with potential antineoplastic activity. Omacetaxine mepesuccinate binds to the 80S ribosome in eukaryotic cells and inhibits protein synthesis by interfering with chain elongation. This agent also induces differentiation and apoptosis in some cancer cell types. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1127" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1127" NCI Thesaurus)
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| IND Code |
105 19125
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| Legacy PDQ ID |
2110
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| LT |
TRD
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| NCI ID |
C1127
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| notation |
CDR0000039476
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| NSC Code |
141633
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| ORIG STY |
Drug/agent
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| prefLabel |
omacetaxine mepesuccinate
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| tui |
T109 T121
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