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Physician Data Query
| Preferred Name | amiodarone hydrochloride | |
| Synonyms |
Nexterone Cordarone |
|
| Definitions |
The hydrochloride salt of an iodine-rich benzofuran derivative with antiarrhythmic and vasodilatory activities. As a class III antiarrhythmic agent, amiodarone blocks the myocardial calcium, potassium and sodium channels in cardiac tissue, resulting in prolongation of the cardiac action potential and refractory period. In addition, this agent inhibits alpha- and beta-adrenergic receptors, resulting in a reduction in sympathetic stimulation of the heart, a negative chronotropic effect, and a decrease in myocardial oxygen demands. Amiodarone may cause vasodilation by stimulation of the release of nitric oxide and cyclooxygenase-dependent relaxing endothelial factors. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C236" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C236" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000039410 |
|
| altLabel |
Nexterone Cordarone
|
|
| CAS Registry |
19774-82-4
|
|
| Component of |
http://purl.bioontology.org/ontology/PDQ/CDR0000039418 |
|
| cui |
C2608296 C0701076 C0700442
|
|
| Date last modified |
2017-11-02
|
|
| definition |
The hydrochloride salt of an iodine-rich benzofuran derivative with antiarrhythmic and vasodilatory activities. As a class III antiarrhythmic agent, amiodarone blocks the myocardial calcium, potassium and sodium channels in cardiac tissue, resulting in prolongation of the cardiac action potential and refractory period. In addition, this agent inhibits alpha- and beta-adrenergic receptors, resulting in a reduction in sympathetic stimulation of the heart, a negative chronotropic effect, and a decrease in myocardial oxygen demands. Amiodarone may cause vasodilation by stimulation of the release of nitric oxide and cyclooxygenase-dependent relaxing endothelial factors. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C236" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C236" NCI Thesaurus)
|
|
| Legacy PDQ ID |
2045
|
|
| LT |
TRD
|
|
| NCI ID |
C236
|
|
| notation |
CDR0000039410
|
|
| NSC Code |
85442
|
|
| ORIG STY |
Drug/agent
|
|
| prefLabel |
amiodarone hydrochloride
|
|
| tui |
T109 T121
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