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| Preferred Name | pentostatin | |
| Synonyms |
2'-deoxycoformycin Covidarabine Nipent CI-825 deoxycoformycin pentostatine PD-81565 (R)-3-(2-deoxy-beta-D-erythro-pentofuranosyl)-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol co-vidarabine DCF |
|
| Definitions |
A purine nucleotide analogue antibiotic isolated from the bacterium Streptomyces antibioticus. Also known as 2'-deoxycoformycin, pentostatin binds to and inhibits adenine deaminase (ADA), an enzyme essential to purine metabolism; ADA activity is greatest in cells of the lymphoid system with T-cells having higher activity than B-cells and T-cell malignancies higher ADA activity than B-cell malignancies. Pentostatin inhibition of ADA appears to result in elevated intracellular levels of dATP which may block DNA synthesis through the inhibition of ribonucleotide reductase. This agent may also inhibit RNA synthesis and may selectively deplete CD26+ lymphocytes. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C732" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C732" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000039210 |
|
| altLabel |
2'-deoxycoformycin Covidarabine Nipent CI-825 deoxycoformycin pentostatine PD-81565 (R)-3-(2-deoxy-beta-D-erythro-pentofuranosyl)-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol co-vidarabine DCF
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|
| CAS Registry |
53910-25-1
|
|
| Component of |
http://purl.bioontology.org/ontology/PDQ/CDR0000038459 http://purl.bioontology.org/ontology/PDQ/CDR0000041476 http://purl.bioontology.org/ontology/PDQ/CDR0000039096 http://purl.bioontology.org/ontology/PDQ/CDR0000042668 http://purl.bioontology.org/ontology/PDQ/CDR0000038893 http://purl.bioontology.org/ontology/PDQ/CDR0000039027 http://purl.bioontology.org/ontology/PDQ/CDR0000041968 |
|
| cui |
C0733529 C0591865 C0733530 C0030896 C1522539
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|
| Date last modified |
2006-09-08
|
|
| definition |
A purine nucleotide analogue antibiotic isolated from the bacterium Streptomyces antibioticus. Also known as 2'-deoxycoformycin, pentostatin binds to and inhibits adenine deaminase (ADA), an enzyme essential to purine metabolism; ADA activity is greatest in cells of the lymphoid system with T-cells having higher activity than B-cells and T-cell malignancies higher ADA activity than B-cell malignancies. Pentostatin inhibition of ADA appears to result in elevated intracellular levels of dATP which may block DNA synthesis through the inhibition of ribonucleotide reductase. This agent may also inhibit RNA synthesis and may selectively deplete CD26+ lymphocytes. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C732" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C732" NCI Thesaurus)
|
|
| IND Code |
52325 16505
|
|
| Legacy PDQ ID |
1832
|
|
| LT |
TRD
|
|
| NCI ID |
C732
|
|
| notation |
CDR0000039210
|
|
| NSC Code |
218321 247520
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|
| ORIG STY |
Drug/agent
|
|
| prefLabel |
pentostatin
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|
| tui |
T195 T114 T121
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