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Physician Data Query
| Preferred Name | cyproterone acetate | |
| Synonyms |
Dianette cyproterone Cyprone Andro-Diane Androcur 6-chloro-1b,2b-dihydro-17a-hydroxy-3'H-cyclopropa[1,2]pregna-1,4,6-triene-3,20-dione Acetate CPTR CyPat chloro-6-hydroxy-17 alpha methylene-1 alpha, 2 alpha pregnadiene-4,6 dione-3, 20 acetate Cyprostat 3'H-cyclopropa(1,2)pregna-1,4,6-triene-3,20-dione, 17-(acetyloxy)-6-chloro-1,2-dihydro-, (1beta,2beta)- SH 714 |
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| Definitions |
The acetate salt of a synthetic steroidal antiandrogen with weak progestational and antineoplastic activities. Cyproterone binds the androgen receptor (AR), thereby preventing androgen-induced receptor activation in target tissues and inhibiting the growth of testosterone-sensitive tumor cells. This agent also exerts progestational agonist properties at the level of the pituitary that reduce luteinizing hormone (LH), resulting in reductions in testicular androgen secretion and serum testosterone levels. Treatment with cyproterone alone results in incomplete suppression of serum testosterone levels. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1059" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1059" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000039203 |
|
| altLabel |
Dianette cyproterone Cyprone Andro-Diane Androcur 6-chloro-1b,2b-dihydro-17a-hydroxy-3'H-cyclopropa[1,2]pregna-1,4,6-triene-3,20-dione Acetate CPTR CyPat chloro-6-hydroxy-17 alpha methylene-1 alpha, 2 alpha pregnadiene-4,6 dione-3, 20 acetate Cyprostat 3'H-cyclopropa(1,2)pregna-1,4,6-triene-3,20-dione, 17-(acetyloxy)-6-chloro-1,2-dihydro-, (1beta,2beta)- SH 714
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| Component of |
http://purl.bioontology.org/ontology/PDQ/CDR0000038980 http://purl.bioontology.org/ontology/PDQ/CDR0000038769 http://purl.bioontology.org/ontology/PDQ/CDR0000285616 |
|
| cui |
C0699709 C0701102 C0591364 C0056855 C0919249 C1511601 C1511602 C0591314 C0010621
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| Date last modified |
2008-09-30
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|
| definition |
The acetate salt of a synthetic steroidal antiandrogen with weak progestational and antineoplastic activities. Cyproterone binds the androgen receptor (AR), thereby preventing androgen-induced receptor activation in target tissues and inhibiting the growth of testosterone-sensitive tumor cells. This agent also exerts progestational agonist properties at the level of the pituitary that reduce luteinizing hormone (LH), resulting in reductions in testicular androgen secretion and serum testosterone levels. Treatment with cyproterone alone results in incomplete suppression of serum testosterone levels. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1059" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1059" NCI Thesaurus)
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| Legacy PDQ ID |
1826
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|
| LT |
TRD
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| NCI ID |
C1059
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| notation |
CDR0000039203
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| ORIG STY |
Drug/agent
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| prefLabel |
cyproterone acetate
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|
| tui |
T109 T121
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