loading...| Preferred Name |
chlorozotocin |
|
| Synonyms |
D-glucopyranose, 2-[[[(2-chloroethyl)nitrosoamino]carbonyl]amino]-2-deoxy |
|
| Definitions |
A glucose-linked chloroethylnitrosourea with potential antineoplastic activity. Chlorozotocin alkylates DNA and proteins, induces the formation of interstrand DNA and DNA-protein crosslinks, and causes DNA strand breakage, thereby damaging DNA and resulting in cell death. This agent has been shown to exhibit antitumor and immunomodulatory effects in cell lines and animal models. Chlorozotocin is a mutagen and is less myelotoxic than other nitrosoureas. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1049" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1049" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000039182 |
|
| altLabel |
D-glucopyranose, 2-[[[(2-chloroethyl)nitrosoamino]carbonyl]amino]-2-deoxy D-glucopyranose DCNU 2-[[[(2-chloroethyl)nitrosamino]carbonyl]amino]-2-deoxy-D-glucose D-glucose, 2-[[[(2-chloroethyl)nitrosoamino]carbonyl]amino]-2-deoxy- (9CI) CLZ CZT 2-[3-(2-chloroethyl)-3-nitrosoureido]-2-deoxy-D-glucopyranose 1-(2-chloroethyl)-1-nitroso-3-(D-glucos-2-yl)urea Chlorozotocyna |
|
| CAS Registry |
54749-90-5 |
|
| cui |
C0055465 |
|
| Date last modified |
2006-12-12 |
|
| definition |
A glucose-linked chloroethylnitrosourea with potential antineoplastic activity. Chlorozotocin alkylates DNA and proteins, induces the formation of interstrand DNA and DNA-protein crosslinks, and causes DNA strand breakage, thereby damaging DNA and resulting in cell death. This agent has been shown to exhibit antitumor and immunomodulatory effects in cell lines and animal models. Chlorozotocin is a mutagen and is less myelotoxic than other nitrosoureas. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1049" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1049" NCI Thesaurus) |
|
| IND Code |
12491 |
|
| Legacy PDQ ID |
1801 |
|
| NCI ID |
C1049 |
|
| notation |
CDR0000039182 |
|
| NSC Code |
178248 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
chlorozotocin |
|
| tui |
T109 T195 |