Preferred Name |
6-azauridine |
|
Synonyms |
3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine riboside |
|
Definitions |
A synthetic triazine analogue of uridine with antimetabolite activity. 6-azauridine inhibits de novo pyrimidine synthesis and DNA synthesis and is converted intracellularly into mono, di-, and triphosphate derivatives, which incorporate into RNA and inhibit protein synthesis. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C291" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C291" NCI Thesaurus) |
|
ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000039158 |
|
altLabel |
3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine riboside 6-azauracil riboside 6-azauracil-.beta.-D-riboside riboazauracil ribo-azauracil 2-beta-D-ribofuranosyl-1,2,4-triazine-3,5(2H,4H)-dione 6-AZUR 1,2,4-triazine-3,5(2H,4H)-dione, 2-beta-D-ribofuranosyl azauridine |
|
cui |
C0004483 |
|
Date last modified |
2010-06-04 |
|
definition |
A synthetic triazine analogue of uridine with antimetabolite activity. 6-azauridine inhibits de novo pyrimidine synthesis and DNA synthesis and is converted intracellularly into mono, di-, and triphosphate derivatives, which incorporate into RNA and inhibit protein synthesis. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C291" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C291" NCI Thesaurus) |
|
Legacy PDQ ID |
1778 |
|
NCI ID |
C291 |
|
notation |
CDR0000039158 |
|
ORIG STY |
Drug/agent |
|
prefLabel |
6-azauridine |
|
tui |
T114 T121 |