loading...| Preferred Name |
aminopterin |
|
| Synonyms |
4-aminofolic acid |
|
| Definitions |
A synthetic derivative of pterins with antineoplastic and immunosuppressive properties. As a folate analogue, aminopterin competes for the folate binding site of the enzyme dihydrofolate reductase, thereby blocking tetrahydrofolate synthesis, and resulting in depletion of nucleotide precursors and inhibition of DNA, RNA and protein synthesis. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C235" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C235" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000039141 |
|
| altLabel |
4-aminofolic acid APGA 4-aminopteroylglutamic acid aminopteroylglutamic acid aminopterin aodium |
|
| CAS Registry |
54-62-6 |
|
| Component of | ||
| cui |
C0282048 C0002583 |
|
| definition |
A synthetic derivative of pterins with antineoplastic and immunosuppressive properties. As a folate analogue, aminopterin competes for the folate binding site of the enzyme dihydrofolate reductase, thereby blocking tetrahydrofolate synthesis, and resulting in depletion of nucleotide precursors and inhibition of DNA, RNA and protein synthesis. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C235" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C235" NCI Thesaurus) |
|
| Legacy PDQ ID |
1761 |
|
| NCI ID |
C235 |
|
| notation |
CDR0000039141 |
|
| NSC Code |
739 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
aminopterin |
|
| tui |
T109 T131 T121 |