loading...| Preferred Name | valdecoxib | |
| Synonyms |
SC 65872 Bextra 4-(5-Methyl-3-phenyl-4-isoxazolyl)benzenesulfonamide |
|
| Definitions |
A sulfonamide derivative and non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic activities. Valdecoxib selectively binds to and inhibits cyclooxygenase (COX)-2, thereby preventing the conversion of arachidonic acid into prostaglandins, which are involved in the regulation of pain, inflammation, and fever. This NSAID does not inhibit COX-1 at therapeutic concentrations and therefore does not interfere with blood coagulation. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1869" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1869" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000038320 |
|
| altLabel |
SC 65872 Bextra 4-(5-Methyl-3-phenyl-4-isoxazolyl)benzenesulfonamide |
|
| CAS Registry |
181695-72-7 |
|
| cui |
C0913246 C1130481 C1101725 |
|
| Date last modified |
2006-05-10 |
|
| definition |
A sulfonamide derivative and non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic activities. Valdecoxib selectively binds to and inhibits cyclooxygenase (COX)-2, thereby preventing the conversion of arachidonic acid into prostaglandins, which are involved in the regulation of pain, inflammation, and fever. This NSAID does not inhibit COX-1 at therapeutic concentrations and therefore does not interfere with blood coagulation. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1869" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1869" NCI Thesaurus) |
|
| Legacy PDQ ID |
10937 |
|
| LT |
TRD |
|
| NCI ID |
C1869 |
|
| notation |
CDR0000038320 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
valdecoxib |
|
| tui |
T109 T121 |