loading...| Preferred Name |
caspofungin acetate |
|
| Synonyms |
MK-0991 |
|
| Definitions |
The acetate salt of an antimycotic echinocandin lipopeptide, semisynthetically derived from a fermentation product of the fungus Glarea lozoyensis. Caspofungin inhibits 1,3-beta-glucan synthase, resulting in decreased synthesis of beta(1,3)-D-glucan (an essential component of the fungal cell wall), weakening of the fungal cell wall, and fungal cell wall rupture. This agent is active against Aspergillus and Candida species. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1724" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1724" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000038182 |
|
| altLabel |
MK-0991 Cancidas L-743,873 |
|
| cui |
C0537895 C0935942 C0935943 C0935984 |
|
| Date last modified |
2006-05-08 |
|
| definition |
The acetate salt of an antimycotic echinocandin lipopeptide, semisynthetically derived from a fermentation product of the fungus Glarea lozoyensis. Caspofungin inhibits 1,3-beta-glucan synthase, resulting in decreased synthesis of beta(1,3)-D-glucan (an essential component of the fungal cell wall), weakening of the fungal cell wall, and fungal cell wall rupture. This agent is active against Aspergillus and Candida species. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1724" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1724" NCI Thesaurus) |
|
| Legacy PDQ ID |
10762 |
|
| LT |
TRD |
|
| NCI ID |
C1724 |
|
| notation |
CDR0000038182 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
caspofungin acetate |
|
| tui |
T116 T121 |