Physician Data Query

Last uploaded: January 31, 2024
Preferred Name

vorinostat

Synonyms

N-hydroxy-N'-phenyloctanediamide

Definitions

A synthetic hydroxamic acid derivative with antineoplastic activity. Vorinostat, a second generation polar-planar compound, binds to the catalytic domain of the histone deacetylases (HDACs). This allows the hydroxamic moiety to chelate zinc ion located in the catalytic pockets of HDAC, thereby inhibiting deacetylation and leading to an accumulation of both hyperacetylated histones and transcription factors. Hyperacetylation of histone proteins results in the upregulation of the cyclin-dependant kinase p21, followed by G1 arrest. Hyperacetylation of non-histone proteins such as tumor suppressor p53, alpha tubulin, and heat-shock protein 90 produces additional anti-proliferative effects. This agent also induces apoptosis and sensitizes tumor cells to cell death processes. Vorinostat crosses the blood-brain barrier. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1796" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1796" NCI Thesaurus)

ID

http://purl.bioontology.org/ontology/PDQ/CDR0000037944

altLabel

N-hydroxy-N'-phenyloctanediamide

SAHA

L-001079038

Zolinza

MSK390

suberoylanilide hydroxamic acid

Component of

http://purl.bioontology.org/ontology/PDQ/CDR0000437143

http://purl.bioontology.org/ontology/PDQ/CDR0000445585

http://purl.bioontology.org/ontology/PDQ/CDR0000440125

http://purl.bioontology.org/ontology/PDQ/CDR0000428333

cui

C0672708

C1738860

C4087052

C1832065

Date last modified

2015-11-05

definition

A synthetic hydroxamic acid derivative with antineoplastic activity. Vorinostat, a second generation polar-planar compound, binds to the catalytic domain of the histone deacetylases (HDACs). This allows the hydroxamic moiety to chelate zinc ion located in the catalytic pockets of HDAC, thereby inhibiting deacetylation and leading to an accumulation of both hyperacetylated histones and transcription factors. Hyperacetylation of histone proteins results in the upregulation of the cyclin-dependant kinase p21, followed by G1 arrest. Hyperacetylation of non-histone proteins such as tumor suppressor p53, alpha tubulin, and heat-shock protein 90 produces additional anti-proliferative effects. This agent also induces apoptosis and sensitizes tumor cells to cell death processes. Vorinostat crosses the blood-brain barrier. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1796" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1796" NCI Thesaurus)

Legacy PDQ ID

10363

LT

TRD

NCI ID

C1796

notation

CDR0000037944

ORIG STY

Drug/agent

prefLabel

vorinostat

tui

T109

T121

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Delete Mapping To Ontology Source
http://purl.bioontology.org/ontology/SNOMEDCT/422523009 SNOMEDCT CUI
http://purl.bioontology.org/ontology/RXNORM/682524 RXNORM CUI
http://purl.bioontology.org/ontology/SNOMEDCT/422505001 SNOMEDCT CUI
http://purl.bioontology.org/ontology/MESH/D000077337 MESH CUI
http://purl.bioontology.org/ontology/NDDF/011760 NDDF CUI
http://purl.bioontology.org/ontology/RXNORM/194337 RXNORM CUI
http://purl.bioontology.org/ontology/ATC/L01XH01 ATC CUI
http://purl.bioontology.org/ontology/SCTSPA/422523009 SCTSPA CUI
http://purl.bioontology.org/ontology/NDFRT/N0000179580 NDFRT CUI
http://purl.bioontology.org/ontology/NDFRT/N0000176066 NDFRT CUI
http://purl.bioontology.org/ontology/VANDF/4025777 VANDF CUI
http://purl.bioontology.org/ontology/SCTSPA/422505001 SCTSPA CUI
http://purl.bioontology.org/ontology/MSHFRE/D000077337 MSHFRE CUI
http://purl.bioontology.org/ontology/MESH/D000077337 MESH CUI
http://purl.obolibrary.org/obo/CHEBI_45716 FYPO LOOM
http://purl.obolibrary.org/obo/CHEBI_45716 CHEBI LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/422505001 SNOMEDCT LOOM
http://www.drugbank.ca/drugs/DB02546 FTC LOOM
http://www.phoc.org.cn/pmo/class/PMO_00026198 PMAPP-PMO LOOM
http://purl.bioontology.org/ontology/MESH/D000077337 MESH LOOM
https://go.drugbank.com/drugs/DB02546 MDM LOOM
http://purl.bioontology.org/ontology/NDDF/011760 NDDF LOOM
http://purl.bioontology.org/ontology/RXNORM/194337 RXNORM LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C111237 RH-MESH LOOM
http://purl.bioontology.org/ontology/ATC/L01XH01 ATC LOOM
http://purl.obolibrary.org/obo/NCIT_C1796 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_45716 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_45716 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_45716 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_45716 DRON LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1796 NCIT LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000176066 NDFRT LOOM
http://purl.bioontology.org/ontology/VANDF/4025777 VANDF LOOM