loading...| Preferred Name | chronic myelogenous leukemia | |
| Synonyms |
myelogenous leukemia, chronic leukemia, chronic myelogenous Chronic Myelogenous Leukemias CML chronic myelocytic leukemia Chronic myelogenous leukemia (CML) CGL Chronic Myeloid Leukemia myelocytic leukemia, chronic CML - Chronic Myelogenous Leukemia chronic granulocytic leukemia granulocytic leukemia, chronic |
|
| Definitions |
The most common chronic myeloproliferative disorder characterized by neutrophilic leukocytosis. It is associated with the Philadelphia (Ph) chromosome and/or the BCR/ABL fusion gene. Most patients are middle-aged or elderly. Common findings at presentation include fatigue, weight loss, anemia, night sweats, and splenomegaly. The disease is bi- or triphasic; an initial indolent chronic phase is followed by an accelerated or blast phase. Allogeneic bone marrow transplantation is currently the only curative therapy (adapted from WHO 2001). Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C3174" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C3174" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000037900 |
|
| altLabel |
myelogenous leukemia, chronic leukemia, chronic myelogenous Chronic Myelogenous Leukemias CML chronic myelocytic leukemia Chronic myelogenous leukemia (CML) CGL Chronic Myeloid Leukemia myelocytic leukemia, chronic CML - Chronic Myelogenous Leukemia chronic granulocytic leukemia granulocytic leukemia, chronic |
|
| cui |
C0279543 |
|
| Date last modified |
2004-12-21 |
|
| definition |
The most common chronic myeloproliferative disorder characterized by neutrophilic leukocytosis. It is associated with the Philadelphia (Ph) chromosome and/or the BCR/ABL fusion gene. Most patients are middle-aged or elderly. Common findings at presentation include fatigue, weight loss, anemia, night sweats, and splenomegaly. The disease is bi- or triphasic; an initial indolent chronic phase is followed by an accelerated or blast phase. Allogeneic bone marrow transplantation is currently the only curative therapy (adapted from WHO 2001). Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C3174" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C3174" NCI Thesaurus) |
|
| Legacy PDQ ID |
1031 |
|
| MENU PARENT |
Disease/diagnosis chronic myeloproliferative neoplasms |
|
| MENU TYPE |
Clinical Trials--CancerType |
|
| NCI ID |
C3174 |
|
| notation |
CDR0000037900 |
|
| ORIG STY |
Neoplasm diagnosis Cancer stage |
|
| prefLabel |
chronic myelogenous leukemia |
|
| tui |
T191 |
|
| subClassOf |