loading...| Preferred Name |
rosiglitazone maleate |
|
| Synonyms |
(+/-)-5-[[4-[2-(Methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-2,4-thiazolidinedione, ( Z )-2-Butenedioate (1:1) |
|
| Definitions |
The maleate salt of rosiglitazone, an orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activity. Rosiglitazone activates peroxisome proliferator-activated receptor gamma (PPAR-gamma), a ligand-activated transcription factor, thereby inducing cell differentiation and inhibiting cell growth and angiogenesis. This agent also modulates the transcription of insulin-responsive genes, inhibits macrophage and monocyte activation, and stimulates adipocyte differentiation. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C2583" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C2583" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000037793 |
|
| altLabel |
(+/-)-5-[[4-[2-(Methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-2,4-thiazolidinedione, ( Z )-2-Butenedioate (1:1) ROS BRL49653 Avandia |
|
| Component of | ||
| cui |
C0795660 C0289314 C0289313 C0875967 |
|
| Date last modified |
2007-02-07 |
|
| definition |
The maleate salt of rosiglitazone, an orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activity. Rosiglitazone activates peroxisome proliferator-activated receptor gamma (PPAR-gamma), a ligand-activated transcription factor, thereby inducing cell differentiation and inhibiting cell growth and angiogenesis. This agent also modulates the transcription of insulin-responsive genes, inhibits macrophage and monocyte activation, and stimulates adipocyte differentiation. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C2583" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C2583" NCI Thesaurus) |
|
| Legacy PDQ ID |
10152 |
|
| LT |
TRD |
|
| NCI ID |
C2583 |
|
| notation |
CDR0000037793 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
rosiglitazone maleate |
|
| tui |
T109 T121 |