loading...| Preferred Name |
osteoclast |
|
| Synonyms |
chondroclast |
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| Definitions |
Morphology: Highly vesicular; markers: Surface: RANK, cFMS (MCSF receptor); Secreted: cathepsin K and TRAP (tartate resistant acid phosphatase); transcription factors: PU.1, cFOS, MITF, NFkB (p52); role or process: tissue remodelling: bone resorption; lineage: hematopoietic, myeloid. A specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes. This cell has the following markers: tartrate-resistant acid phosphatase type 5-positive, PU.1-positive, c-fos-positive, nuclear factor NF-kappa-B p100 subunit-positive, tumor necrosis factor receptor superfamily member 11A-positive and macrophage colony-stimulating factor 1 receptor-positive. |
|
| ID |
http://purl.obolibrary.org/obo/CL_0000092 |
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| comment |
Morphology: Highly vesicular; markers: Surface: RANK, cFMS (MCSF receptor); Secreted: cathepsin K and TRAP (tartate resistant acid phosphatase); transcription factors: PU.1, cFOS, MITF, NFkB (p52); role or process: tissue remodelling: bone resorption; lineage: hematopoietic, myeloid. |
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| capable of | ||
| database_cross_reference |
MESH:D010010 CALOHA:TS-0721 BTO:0000968 FMA:66781 |
|
| definition |
A specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes. This cell has the following markers: tartrate-resistant acid phosphatase type 5-positive, PU.1-positive, c-fos-positive, nuclear factor NF-kappa-B p100 subunit-positive, tumor necrosis factor receptor superfamily member 11A-positive and macrophage colony-stimulating factor 1 receptor-positive. |
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| develops_from | ||
| has part |
http://purl.obolibrary.org/obo/PR_000001944 http://purl.obolibrary.org/obo/PR_000007597 http://purl.obolibrary.org/obo/PR_000011178 |
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| has plasma membrane part | ||
| has_related_synonym |
chondroclast |
|
| label |
osteoclast |
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| prefixIRI |
CL:0000092 |
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| prefLabel |
osteoclast |
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| treeView | ||
| subClassOf |
http://purl.obolibrary.org/obo/CL_0001035 http://purl.obolibrary.org/obo/PR_000050567 |