Preferred Name |
Estramustine |
|
Synonyms |
|
|
Definitions |
A synthetic molecule combining estradiol and nornitrogen mustard through a carbamate link. Estramustine and its major metabolite estramustine bind to microtubule-associated proteins (MAPs) and tubulin, thereby inhibiting microtubule dynamics and leading to anaphase arrest in a dose-dependent fashion. This agent also exhibits anti-androgenic effects. (NCI04)/NCI-GLOSS Definition: A combination of the hormone estradiol (an estrogen) and nitrogen mustard (an anticancer drug). Used in the palliative therapy of prostate cancer. |
|
ID |
http://www.semanticweb.org/ontologies/2018/1/ProstateCancer.owl#Estramustine |
|
ChineseLabel |
雌二醇氮芥 |
|
definition |
A synthetic molecule combining estradiol and nornitrogen mustard through a carbamate link. Estramustine and its major metabolite estramustine bind to microtubule-associated proteins (MAPs) and tubulin, thereby inhibiting microtubule dynamics and leading to anaphase arrest in a dose-dependent fashion. This agent also exhibits anti-androgenic effects. (NCI04)/NCI-GLOSS Definition: A combination of the hormone estradiol (an estrogen) and nitrogen mustard (an anticancer drug). Used in the palliative therapy of prostate cancer. |
|
label |
Estramustine |
|
prefixIRI |
ProstateCancer:Estramustine |
|
prefLabel |
Estramustine |
|
reference |
NCI Thesaurus Code:C479 |
|
synonyms |
estradiol 3-bis(2-chloroethyl)carbamate Estramustine estra-1,3,5(10)triene-317beta-diol 3-[N,N-bis-(2-chloroethyl)carbamate] Estradiol 3-[bis(2-chloroethyl)carbamate] 17beta-(estra-1,3,5(10)-triene-3,17-diol 3-(bis(2-chloroethyl)carbamate)) ESTRAMUSTINE estramustine Leo 275 RO 21-8837 |
|
URL |
https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C479 |
|
subClassOf |
http://www.semanticweb.org/ontologies/2018/1/ProstateCancer.owl#Chemotherapy |