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Prostate Cancer Ontology
Last uploaded:
June 6, 2023
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| Preferred Name | Enzalutamide | |
| Synonyms |
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| Definitions |
An orally bioavailable, organic, non-steroidal small molecule targeting the androgen receptor (AR) with potential antineoplastic activity. Through a mechanism that is reported to be different from other approved AR antagonists, enzalutamide inhibits the activity of prostate cancer cell ARs, which may result in a reduction in prostate cancer cell proliferation and, correspondingly, a reduction in the serum prostate specific antigen (PSA) level. AR over-expression in prostate cancer represents a key mechanism associated with prostate cancer hormone resistance. |
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| ID |
http://www.semanticweb.org/ontologies/2018/1/ProstateCancer.owl#Enzalutamide |
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| ChineseLabel |
安扎鲁胺
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| definition |
An orally bioavailable, organic, non-steroidal small molecule targeting the androgen receptor (AR) with potential antineoplastic activity. Through a mechanism that is reported to be different from other approved AR antagonists, enzalutamide inhibits the activity of prostate cancer cell ARs, which may result in a reduction in prostate cancer cell proliferation and, correspondingly, a reduction in the serum prostate specific antigen (PSA) level. AR over-expression in prostate cancer represents a key mechanism associated with prostate cancer hormone resistance.
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| label |
Enzalutamide
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| prefixIRI |
ProstateCancer:Enzalutamide
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| prefLabel |
Enzalutamide
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| reference |
NCI Thesaurus Code:C71744
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| synonyms |
Enzalutamide 4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxo-1-imidazolidinyl)-2-fluoro-N- ENZALUTAMIDE ASP9785 Benzamide MDV3100 Xtandi methyl-
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| URL |
https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C71744 |
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