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Prostate Cancer Ontology
| Preferred Name | Cyproterone Acetate | |
| Synonyms |
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| Definitions |
The acetate salt of a synthetic steroidal antiandrogen with weak progestational and antineoplastic activities. Cyproterone binds the androgen receptor (AR), thereby preventing androgen-induced receptor activation in target tissues and inhibiting the growth of testosterone-sensitive tumor cells. This agent also exerts progestational agonist properties at the level of the pituitary that reduce luteinizing hormone (LH), resulting in reductions in testicular androgen secretion and serum testosterone levels. Treatment with cyproterone alone results in incomplete suppression of serum testosterone levels./NCI-GLOSS Definition: A synthetic hormone being studied for treatment of hot flashes in men with prostate cancer who have had both testicles removed by surgery. |
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| ID |
http://www.semanticweb.org/ontologies/2018/1/ProstateCancer.owl#Cyproterone_acetate_(CPA) |
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| ChineseLabel |
醋酸环丙氯地孕酮
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| definition |
The acetate salt of a synthetic steroidal antiandrogen with weak progestational and antineoplastic activities. Cyproterone binds the androgen receptor (AR), thereby preventing androgen-induced receptor activation in target tissues and inhibiting the growth of testosterone-sensitive tumor cells. This agent also exerts progestational agonist properties at the level of the pituitary that reduce luteinizing hormone (LH), resulting in reductions in testicular androgen secretion and serum testosterone levels. Treatment with cyproterone alone results in incomplete suppression of serum testosterone levels./NCI-GLOSS Definition: A synthetic hormone being studied for treatment of hot flashes in men with prostate cancer who have had both testicles removed by surgery.
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Cyproterone Acetate
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| prefLabel |
Cyproterone Acetate
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| reference |
NCI Thesaurus Code:C1059
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| synonyms |
3'H-Cyclopropa(1,2)pregna-1,4,6-triene-3,20-dione, 17-(Acetyloxy)-6-chloro-1,2-dihydro-, (1beta,2beta)- Cyproterone Acetate Chloro-6-hydroxy-17 Alpha Methylene-1 Alpha, 2 Alpha Pregnadiene-4,6 Dione-3, 20 Acetate Cyproteronazetat CYPROTERONE ACETATE 6-Chloro-1b,2b-dihydro-17a-hydroxy-3'H-cyclopropa[1,2]pregna-1,4,6-triene-3,20-dione Acetat
Andro-Diane Cyproteroni Acetas cyproterone acetate Androcur CyPat Cyprone Cyprostat Diane Dianette SH 714 SH-714
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| URL |
https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C1059 |
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| subClassOf |
http://www.semanticweb.org/ontologies/2018/1/ProstateCancer.owl#Steroidal_anti-androgens |
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