loading...| Preferred Name | Alpha-tocopherol | |
| Synonyms |
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| Definitions |
The orally bioavailable alpha form of the naturally-occurring fat-soluble vitamin E, with potent antioxidant and cytoprotective activities. Upon administration, alpha-tocopherol neutralizes free radicals, thereby protecting tissues and organs from oxidative damage. Alpha-tocopherol gets incorporated into biological membranes, prevents protein oxidation and inhibits lipid peroxidation, thereby maintaining cell membrane integrity and protecting the cell against damage. In addition, alpha-tocopherol inhibits the activity of protein kinase C (PKC) and PKC-mediated pathways. Alpha-tocopherol also modulates the expression of various genes, plays a key role in neurological function, inhibits platelet aggregation and enhances vasodilation. Compared with other forms of tocopherol, alpha-tocopherol is the most biologically active form and is the form that is preferentially absorbed and retained in the body. CRCH Definition: Tocopherol with three methyl groups on its chromanol ring." |
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| ID |
http://www.semanticweb.org/ontologies/2018/1/ProstateCancer.owl#Alpha-tocopherol |
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| ChineseLabel |
α-生育酚 |
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| definition |
The orally bioavailable alpha form of the naturally-occurring fat-soluble vitamin E, with potent antioxidant and cytoprotective activities. Upon administration, alpha-tocopherol neutralizes free radicals, thereby protecting tissues and organs from oxidative damage. Alpha-tocopherol gets incorporated into biological membranes, prevents protein oxidation and inhibits lipid peroxidation, thereby maintaining cell membrane integrity and protecting the cell against damage. In addition, alpha-tocopherol inhibits the activity of protein kinase C (PKC) and PKC-mediated pathways. Alpha-tocopherol also modulates the expression of various genes, plays a key role in neurological function, inhibits platelet aggregation and enhances vasodilation. Compared with other forms of tocopherol, alpha-tocopherol is the most biologically active form and is the form that is preferentially absorbed and retained in the body. CRCH Definition: Tocopherol with three methyl groups on its chromanol ring." |
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| label |
Alpha-tocopherol |
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| prefixIRI |
ProstateCancer:Alpha-tocopherol |
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| prefLabel |
Alpha-tocopherol |
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| reference |
NCI Thesaurus Code:C74960 |
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| synonyms |
Alpha-Tocopherol 3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-ol Alpha-tocopherol ALPHA.-TOCOPHEROL 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)chroman-6-ol |
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| URL |
https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C74960 |
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| subClassOf |
http://www.semanticweb.org/ontologies/2018/1/ProstateCancer.owl#Additives |