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Orphanet Rare Disease Ontology
| Preferred Name | American trypanosomiasis | |
| Synonyms |
Chagas disease |
|
| Definitions |
A tropical disease mainly found in latin America and transmitted by triatomine insects (mostly <i>Triatoma infestans</i> and <i>Rhodnius prolixus</i> and <i>Panstrongylus megistus</i>) harboring the hemoflagellate protozoan parasite <i>Trypanosoma cruzi</i>. The disease is characterized by an acute phase which is either asymptomatic or manifest with fever, inflammation at the inoculation site (inoculation chancre or chagoma), unilateral palpebral edema called the Romaña sign (when the triatomine bite occurs near the eye), enlarged lymph nodes, and splenomegaly. The chronic phase is lifelong and development of chagasic cardiomyopathy (30%; complex arrhythmias, heart failure, and thromboembolic events), digestive (10%; megaoesophagus and megacolon), neurological (10%; stroke, peripheral neuropathy and autonomic dysfunction), or mixed alterations (10%) may be observed. These can all lead to high morbidity and mortality rates. |
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| ID |
http://www.orpha.net/ORDO/Orphanet_3386 |
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| alternative_term |
Chagas disease
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|
| definition |
A tropical disease mainly found in latin America and transmitted by triatomine insects (mostly <i>Triatoma infestans</i> and <i>Rhodnius prolixus</i> and <i>Panstrongylus megistus</i>) harboring the hemoflagellate protozoan parasite <i>Trypanosoma cruzi</i>. The disease is characterized by an acute phase which is either asymptomatic or manifest with fever, inflammation at the inoculation site (inoculation chancre or chagoma), unilateral palpebral edema called the Romaña sign (when the triatomine bite occurs near the eye), enlarged lymph nodes, and splenomegaly. The chronic phase is lifelong and development of chagasic cardiomyopathy (30%; complex arrhythmias, heart failure, and thromboembolic events), digestive (10%; megaoesophagus and megacolon), neurological (10%; stroke, peripheral neuropathy and autonomic dysfunction), or mixed alterations (10%) may be observed. These can all lead to high morbidity and mortality rates.
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| definition_citation |
Orphanet
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| expertlink |
https://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=en&Expert=3386 |
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| has_age_of_onset |
All ages
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| has_inheritance |
Not applicable
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| hasDbXref |
ICD-10:B57.1 MeSH:D014355 ICD-10:B57.0 ICD-10:B57.5 ICD-10:B57.3 ICD-10:B57.4 MedDRA:10001935 ICD-11:1F53 ICD-11:1F53.4 ICD-11:1F53.3 ICD-11:1F53.1 ICD-11:1F53.2 UMLS:C0041234 ICD-10:B57.2
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| label |
American trypanosomiasis
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|
| notation |
ORPHA:3386
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| part_of | ||
| prefixIRI |
ORDO:Orphanet_3386
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| prefLabel |
American trypanosomiasis
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| present_in |
Germany AND has_point_prevalence_range : <1 / 1 000 000 Netherlands AND has_point_prevalence_range : <1 / 1 000 000 Spain AND has_point_prevalence_range : 1-9 / 100 000 Europe AND has_point_prevalence_range : 1-9 / 1 000 000 Italy AND has_point_prevalence_range : 1-9 / 1 000 000 Switzerland AND has_point_prevalence_range : 1-9 / 100 000 United Kingdom AND has_point_prevalence_range : <1 / 1 000 000 Portugal AND has_point_prevalence_range : <1 / 1 000 000 France AND has_point_prevalence_range : 1-9 / 1 000 000 Belgium AND has_point_prevalence_range : 1-9 / 1 000 000 United States AND has_point_prevalence_average_value : 95.0 AND has_point_prevalence_range : 6-9 / 10 000
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