loading...| Preferred Name |
Apolipoprotein A-I |
|
| Synonyms |
Apolipoprotéine A1 Apo AI Apolipoprotein A-1 |
|
| Definitions |
The most abundant protein component of HIGH DENSITY LIPOPROTEINS or HDL. This protein serves as an acceptor for CHOLESTEROL released from cells thus promoting efflux of cholesterol to HDL then to the LIVER for excretion from the body (reverse cholesterol transport). It also acts as a cofactor for LECITHIN CHOLESTEROL ACYLTRANSFERASE that forms CHOLESTEROL ESTERS on the HDL particles. Mutations of this gene APOA1 cause HDL deficiency, such as in FAMILIAL ALPHA LIPOPROTEIN DEFICIENCY DISEASE and i (source : MSH) |
|
| ID |
http://doe-generated-ontology.com/OntoAD#C0085201 |
|
| altLabel |
Apolipoprotéine A1 Apo AI Apolipoprotein A-1 Apo A-I ApoA-I ApoA-I Apo AI Apo A1 ApoA-1 Apolipoprotéine AI Apolipoprotein AI Apolipoprotéine A-1 Apolipoprotéine de type A-1 Apolipoprotein A1 ApoA-1 Apolipoprotéine de type A-I Apo A-1 Apo A1 Apo A-I Apo A-1 |
|
| definition |
The most abundant protein component of HIGH DENSITY LIPOPROTEINS or HDL. This protein serves as an acceptor for CHOLESTEROL released from cells thus promoting efflux of cholesterol to HDL then to the LIVER for excretion from the body (reverse cholesterol transport). It also acts as a cofactor for LECITHIN CHOLESTEROL ACYLTRANSFERASE that forms CHOLESTEROL ESTERS on the HDL particles. Mutations of this gene APOA1 cause HDL deficiency, such as in FAMILIAL ALPHA LIPOPROTEIN DEFICIENCY DISEASE and i (source : MSH) |
|
| hiddenLabel |
ApolipoproteinA-I ApolipoprotéineA-I |
|
| prefixIRI |
OntoAD:C0085201 |
|
| prefLabel |
Apolipoprotéine A-I Apolipoprotein A-I |
|
| subClassOf |