loading...| Preferred Name | Topotecan | |
| Synonyms |
topotecane topotecan CC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4ccc(O)c(CN(C)C)c4cc3Cn1c2=O InChI=1S/C23H23N3O5/c1-4-23(30)16-8-18-20-12(9-26(18)21(28)15(16)11-31-22(23)29)7-13-14(10-25(2)3)19(27)6-5-17(13)24-20/h5-8,27,30H,4,9-11H2,1-3H3/t23-/m0/s1 InChIKey=UCFGDBYHRUNTLO-QHCPKHFHSA-N topotecanum 9-[(dimethylamino)methyl]-10-hydroxy-(4S)-camptothecin C23H23N3O5 Topotecan (4S)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione |
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| Definitions |
A pyranoindolizinoquinoline used as an antineoplastic agent. It is a derivative of camptothecin and works by binding to the topoisomerase I-DNA complex and preventing religation of these 328 single strand breaks. |
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| ID |
http://purl.obolibrary.org/obo/CHEBI_63632 |
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| database_cross_reference |
CiteXplore:22028494 CiteXplore:21352915 Patent:EP321122 ChemIDplus:123948-87-8 CiteXplore:22190039 CiteXplore:21255983 KEGG COMPOUND:123948-87-8 CiteXplore:22075006 Wikipedia:Topotecan CiteXplore:20574789 CiteXplore:22136714 KEGG COMPOUND:C11158 CiteXplore:21910214 DrugBank:DB01030 Reaxys:4279441 KEGG DRUG:D08618 |
|
| definition |
A pyranoindolizinoquinoline used as an antineoplastic agent. It is a derivative of camptothecin and works by binding to the topoisomerase I-DNA complex and preventing religation of these 328 single strand breaks. |
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| has_alternative_id |
CHEBI:9634 |
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| has_exact_synonym |
Topotecan (4S)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione |
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| has_related_synonym |
topotecane topotecan CC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4ccc(O)c(CN(C)C)c4cc3Cn1c2=O InChI=1S/C23H23N3O5/c1-4-23(30)16-8-18-20-12(9-26(18)21(28)15(16)11-31-22(23)29)7-13-14(10-25(2)3)19(27)6-5-17(13)24-20/h5-8,27,30H,4,9-11H2,1-3H3/t23-/m0/s1 InChIKey=UCFGDBYHRUNTLO-QHCPKHFHSA-N topotecanum 9-[(dimethylamino)methyl]-10-hydroxy-(4S)-camptothecin C23H23N3O5 |
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| has_RxCUI |
57308 |
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| id |
CHEBI:63632 |
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| imported from | ||
| label |
Topotecan topotecan |
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| notation |
CHEBI:63632 |
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| prefLabel |
Topotecan |
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| subClassOf |