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Ontology of Drug Neuropathy Adverse Events
| Preferred Name | Misoprostol | |
| Synonyms |
(11-alpha,13E)-(+-)-11,16-dihydroxy-16-methyl-9-oxoprost-13-en-1-oic acid methyl ester Methyl (+-)-11-alpha,16-dihydroxy-16-methyl-9-oxoprost-13-en-1-oate Cytotec (+-)-methyl (1R,2R,3R)-3-hydroxy-2-((E)-(4RS)-4-hydroxy-4-methyl-1-octenyl)-5-oxocyclopentaneheptanoate misoprostolum misoprostol Arthrotec |
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| Definitions |
A diastereoisomeric mixture composed of approximately equal amounts of a double racemate of four of the sixteen possible diastereoisomers of methyl (13E)-11,16-dihydroxy-16-methyl-9-oxoprost-13-en-1-oate that is racemic prostaglandin E1 which is lacking the hydroxy group at position 15, but which has an additional hydroxy group at position 16. It is a synthetic prostaglandin E1 analogue, used in the treatment of gastric and duodenal ulcers. A weak abortifacient, it is also used for cervical ripening prior to surgical termination of pregnancy. The (11R,16S)-diastereoisomer is the pharmacologically active form. |
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| ID |
http://purl.obolibrary.org/obo/CHEBI_63610 |
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| database_cross_reference |
CiteXplore:19740175 Reaxys:4155643 KEGG DRUG:59122-46-2 CiteXplore:11136959 Patent:US3965143 ChemIDplus:59122-46-2 CiteXplore:1417145 CiteXplore:2109814 CiteXplore:10945193 Patent:BE827127 CiteXplore:3080288 KEGG DRUG:D00419 CiteXplore:18690850 DrugBank:DB00929 Wikipedia:Misoprostol CiteXplore:10949752
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| definition |
A diastereoisomeric mixture composed of approximately equal amounts of a double racemate of four of the sixteen possible diastereoisomers of methyl (13E)-11,16-dihydroxy-16-methyl-9-oxoprost-13-en-1-oate that is racemic prostaglandin E1 which is lacking the hydroxy group at position 15, but which has an additional hydroxy group at position 16. It is a synthetic prostaglandin E1 analogue, used in the treatment of gastric and duodenal ulcers. A weak abortifacient, it is also used for cervical ripening prior to surgical termination of pregnancy. The (11R,16S)-diastereoisomer is the pharmacologically active form.
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| has_alternative_id |
CHEBI:6952
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| has_related_synonym |
(11-alpha,13E)-(+-)-11,16-dihydroxy-16-methyl-9-oxoprost-13-en-1-oic acid methyl ester Methyl (+-)-11-alpha,16-dihydroxy-16-methyl-9-oxoprost-13-en-1-oate Cytotec (+-)-methyl (1R,2R,3R)-3-hydroxy-2-((E)-(4RS)-4-hydroxy-4-methyl-1-octenyl)-5-oxocyclopentaneheptanoate misoprostolum misoprostol Arthrotec
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| has_RxCUI |
42331
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| id |
CHEBI:63610
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| imported from | ||
| label |
Misoprostol misoprostol
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| notation |
CHEBI:63610
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| prefLabel |
Misoprostol
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| subClassOf |
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