Ontology of Drug Adverse Events

Last uploaded: January 12, 2019
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Preferred Name

Didanosine [Chemical/Ingredient]
Synonyms
ID

http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000006111
code

C22566
Display_Name

Didanosine
imported from

http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl
label

Didanosine [Chemical/Ingredient]
MeSH_CUI

M0024535
MeSH_Definition

A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. Didanosine is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase; ddI is then metabolized to dideoxyadenosine triphosphate, its putative active metabolite.
MeSH_DUI

D016049
MeSH_Name

Didanosine
NUI

N0000006111
prefixIRI

NDF-RT:N0000006111
prefLabel

Didanosine [Chemical/Ingredient]
RxNorm_CUI

3364
RxNorm_Name

Didanosine
Synonym

2',3'-Dideoxyinosine

ddI (Antiviral)

Dideoxyinosine

Inosine, 2',3'-dideoxy-
UMLS_CUI

C0012133
subClassOf

http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000008090

http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000008043
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