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Ontology of Drug Adverse Events
Last uploaded:
January 12, 2019
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| Preferred Name | Zalcitabine [Chemical/Ingredient] | |
| Synonyms |
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|
| ID |
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000006107 |
|
| code |
C22558
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|
| Display_Name |
Zalcitabine
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| imported from | ||
| label |
Zalcitabine [Chemical/Ingredient]
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| MeSH_CUI |
M0024532
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| MeSH_Definition |
A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication at low concentrations, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal toxic side effect is axonal degeneration resulting in peripheral neuropathy.
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| MeSH_DUI |
D016047
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| MeSH_Name |
Zalcitabine
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| NUI |
N0000006107
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| prefixIRI |
NDF-RT:N0000006107
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|
| prefLabel |
Zalcitabine [Chemical/Ingredient]
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| RxNorm_CUI |
3363
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| RxNorm_Name |
Zalcitabine
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| Synonym |
2',3'-Dideoxycytidine ddC (Antiviral) Cytidine, 2',3'-dideoxy- Dideoxycytidine
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| UMLS_CUI |
C0012132
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| subClassOf |
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| Mapping To | Ontology | Source |
|---|---|---|
| http://purl.bioontology.org/ontology/NDFRT/N0000006107 | NDFRT | LOOM |