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Operational Ontology for Oncology
Last uploaded:
June 15, 2026
| Acronym | O3 |
| Visibility | Public |
| Description | The Operational Ontology for Oncology is formalized, machine-readable knowledge representation that defines and standardizes the concepts, terms, value sets and relationships used in cancer care. O3 is an operational ontology, meaning that its format and content is optimized for clinical process implementation with current clinical data systems. It is formed through multi-professional society based, multi-institutional consensus formation with physicians, physicists, informaticists and other domain experts in the context of the American Association of Physicists in Medicine (AAPM). It is formed in collaboration with and has been endorse by multiple professional societies including American Society of Radiation Oncology (ASTRO), Canadian Association for Radiation Oncology (CARO) and the European Society for Therapeutic Radiation Oncology (ESTRO). Its primary purpose is to ensure semantic interoperability of comprehensive data sets from disparate sources like electronic health records (EHRs), lab systems, and research databases to be accurately aggregated and understood by different systems. This is particularly crucial for a complex and data-rich field like oncology. O3 was first published in the article, Operational Ontology for Oncology (O3): A Professional Society-Based, Multistakeholder, Consensus-Driven Informatics Standard Supporting Clinical and Research Use of Real-World Data From Patients Treated for Cancer. Int J Radiat Oncol Biol Phys. 2023 Nov 1;117(3):533-550. doi: 10.1016/j.ijrobp.2023.05.033. Epub 2023 May 26. PMID: 37244628; PMCID: PMC10741247. The home web site is at o3standard.net. The site is used as the main mechanism for gathering public comments and accessing future, current and prior versions of the ontology in json format. |
| Status | Beta |
| Format | OWL |
| Contact | Katherine Mayo, Ph D ([email protected]) Ying Xiao, Ph D ([email protected]) Kristy Brock, Ph D ([email protected]) Charles Mayo, Ph D ([email protected]) |
| Creation date | June 15, 2026
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| Deprecated |
false
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| Modification date | June 3, 2026
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| Notes |
In addition to new classes introduced to the O3 Ontology, the new OWL file includes an update of the IRI from example.org to a permanent, stable identifier.
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| Object creation date property |
http://purl.org/dc/elements/1.1/created
http://purl.org/dc/elements/1.1/created
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| Object modification date property |
http://purl.org/dc/elements/1.1/modified
http://purl.org/dc/elements/1.1/modified
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| Submission date | June 15, 2026
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| Version information |
2.0
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| uri |
https://w3id.org/O3_Ontology
https://w3id.org/O3_Ontology
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| Version | Released | Uploaded | Downloads |
|---|---|---|---|
| 2.0 (Parsed, Indexed, Metrics, Annotator) | 06/15/2026 | 06/15/2026 | OWL | CSV | RDF/XML | Diff |
| 1.0 (Archived) | 10/16/2025 | 10/16/2025 | OWL | Diff |
| 0.5.1 (Archived) | 08/27/2025 | 08/27/2025 | OWL | Diff |
| 0.5 (Archived) | 08/22/2025 | 08/22/2025 | OWL |
| unknown (Archived) | 08/22/2025 | 08/22/2025 | OWL |
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