Jump to:
loading...
Preferred Name

obsolete regulation of molecular function, epigenetic
Synonyms

regulation of protein activity, epigenetic
Definitions

OBSOLETE. Any heritable epigenetic process that modulates the frequency, rate or extent of protein function by self-perpetuating conformational conversions of normal proteins in healthy cells. This is distinct from, though mechanistically analogous to, disease states associated with prion propagation and amyloidogenesis. A single protein, if it carries a glutamine/asparagine-rich ('prion') domain, can sometimes stably exist in at least two distinct physical states, each associated with a different phenotype; propagation of one of these traits is achieved by a self-perpetuating change in the protein from one form to the other, mediated by conformational changes in the glutamine/asparagine-rich domain. Prion domains are both modular and transferable to other proteins, on which they can confer a heritable epigenetic alteration of function; existing bioinformatics data indicate that they are rare in non-eukarya, but common in eukarya. This term was obsoleted because it is not an active process.
ID

http://purl.obolibrary.org/obo/GO_0040030
Obsolete

true
comment

This term was obsoleted because it is not an active process.
alternative label

regulation of protein activity, epigenetic
definition

OBSOLETE. Any heritable epigenetic process that modulates the frequency, rate or extent of protein function by self-perpetuating conformational conversions of normal proteins in healthy cells. This is distinct from, though mechanistically analogous to, disease states associated with prion propagation and amyloidogenesis. A single protein, if it carries a glutamine/asparagine-rich ('prion') domain, can sometimes stably exist in at least two distinct physical states, each associated with a different phenotype; propagation of one of these traits is achieved by a self-perpetuating change in the protein from one form to the other, mediated by conformational changes in the glutamine/asparagine-rich domain. Prion domains are both modular and transferable to other proteins, on which they can confer a heritable epigenetic alteration of function; existing bioinformatics data indicate that they are rare in non-eukarya, but common in eukarya.

This term was obsoleted because it is not an active process.
has exact synonym

regulation of protein activity, epigenetic
has_obo_namespace

biological_process
id

GO:0040030
label

obsolete regulation of molecular function, epigenetic
notation

GO:0040030
note

OBSOLETE. Any heritable epigenetic process that modulates the frequency, rate or extent of protein function by self-perpetuating conformational conversions of normal proteins in healthy cells. This is distinct from, though mechanistically analogous to, disease states associated with prion propagation and amyloidogenesis. A single protein, if it carries a glutamine/asparagine-rich ('prion') domain, can sometimes stably exist in at least two distinct physical states, each associated with a different phenotype; propagation of one of these traits is achieved by a self-perpetuating change in the protein from one form to the other, mediated by conformational changes in the glutamine/asparagine-rich domain. Prion domains are both modular and transferable to other proteins, on which they can confer a heritable epigenetic alteration of function; existing bioinformatics data indicate that they are rare in non-eukarya, but common in eukarya.

This term was obsoleted because it is not an active process.
owl:deprecated

true
preferred label

obsolete regulation of molecular function, epigenetic
prefLabel

obsolete regulation of molecular function, epigenetic
term tracker item

https://github.com/geneontology/go-ontology/issues/22203
Add comment
Add proposal
Delete Subject Author Type Created
No notes to display
Create mapping