loading...| Preferred Name |
leflunomide |
|
| Synonyms |
Leflunomide 5-methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide Arava leflunomida leflunomide 5-Methyl-N-(4-(trifluoromethyl)phenyl)-4-isoxazolecarboxamide alpha,alpha,alpha-Trifluoro-5-methyl-4-isoxazolecarboxy-p-toluidide leflunomidum 5-Methylisoxazole-4-carboxylic acid (4-trifluoromethyl)anilide |
|
| Definitions |
A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide. |
|
| ID |
http://purl.obolibrary.org/obo/CHEBI_6402 |
|
| charge |
0 |
|
| database_cross_reference |
PMID:15385935 CAS:75706-12-6 PMID:16778342 PMID:11391470 PMID:19715969 KEGG:C07905 DrugBank:DB01097 PMID:16202258 PMID:19190124 PMID:18663553 Patent:DE2854439 PMID:9777697 Drug_Central:1552 PMID:18173611 PMID:15537652 PMID:11067959 PMID:17366662 PMID:11718154 PMID:15789891 PMID:15489872 PMID:15188371 PMID:15652966 PMID:11475244 PMID:11053058 PMID:19344337 Reaxys:4323174 PMID:11333342 Beilstein:4323174 PMID:10890256 PMID:16645972 LINCS:LSM-3771 PMID:11043056 PMID:15127974 PMID:17604599 PMID:11994686 PMID:9075844 PMID:16769661 PMID:14622739 PMID:16284916 PMID:10515382 PMID:15127968 PMID:18034546 PMID:15030575 PMID:11522581 PMID:17646975 PMID:11876141 PMID:12017890 PMID:16638062 PMID:15934905 PMID:18688040 PMID:15899055 PMID:12074690 PMID:8610393 PMID:10702725 PMID:18413415 PMID:11707749 PMID:7496341 PMID:19751817 PMID:15214907 HMDB:HMDB0015229 PMID:16106593 PMID:19581389 PMID:15665760 PMID:12833393 PMID:19770782 PMID:19169882 PMID:9123314 PMID:16638420 PMID:16142756 PMID:9625011 PMID:17854740 PMID:11884931 PMID:16688677 PMID:11271257 KEGG:D00749 PMID:11340750 PMID:7676489 Wikipedia:Leflunomide PMID:18496682 Patent:US4284786 |
|
| definition |
A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide. |
|
| formula |
C12H9F3N2O2 |
|
| has exact synonym |
Leflunomide 5-methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide |
|
| has role |
http://purl.obolibrary.org/obo/CHEBI_35705 http://purl.obolibrary.org/obo/CHEBI_37153 http://purl.obolibrary.org/obo/CHEBI_35610 http://purl.obolibrary.org/obo/CHEBI_38637 http://purl.obolibrary.org/obo/CHEBI_68542 http://purl.obolibrary.org/obo/CHEBI_68543 http://purl.obolibrary.org/obo/CHEBI_50908 http://purl.obolibrary.org/obo/CHEBI_35475 |
|
| has_obo_namespace |
chebi_ontology |
|
| has_related_synonym |
Arava leflunomida leflunomide 5-Methyl-N-(4-(trifluoromethyl)phenyl)-4-isoxazolecarboxamide alpha,alpha,alpha-Trifluoro-5-methyl-4-isoxazolecarboxy-p-toluidide leflunomidum 5-Methylisoxazole-4-carboxylic acid (4-trifluoromethyl)anilide |
|
| id |
CHEBI:6402 |
|
| in_subset | ||
| inchi |
InChI=1S/C12H9F3N2O2/c1-7-10(6-16-19-7)11(18)17-9-4-2-8(3-5-9)12(13,14)15/h2-6H,1H3,(H,17,18) |
|
| inchikey |
VHOGYURTWQBHIL-UHFFFAOYSA-N |
|
| label |
leflunomide |
|
| mass |
270.20730 |
|
| monoisotopicmass |
270.06161 |
|
| notation |
CHEBI:6402 |
|
| prefLabel |
leflunomide |
|
| smiles |
Cc1oncc1C(=O)Nc1ccc(cc1)C(F)(F)F |
|
| subClassOf |
http://purl.obolibrary.org/obo/CHEBI_55373 |