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National Drug File - Reference Terminology
Last uploaded:
July 6, 2018
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| Preferred Name | Didanosine [Chemical/Ingredient] | |
| Synonyms |
Dideoxyinosine Inosine, 2',3'-dideoxy- Didanosine ddI (Antiviral) 2',3'-Dideoxyinosine |
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| ID |
http://purl.bioontology.org/ontology/NDFRT/N0000006111 |
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| altLabel |
Dideoxyinosine Inosine, 2',3'-dideoxy- Didanosine ddI (Antiviral) 2',3'-Dideoxyinosine
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| cui |
C0012133
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| Ingredient of | ||
| MESH DEFINITION |
A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. Didanosine is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase; ddI is then metabolized to dideoxyadenosine triphosphate, its putative active metabolite.
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| MESH DUI |
D016049
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| MeSH name |
Didanosine
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| MESH UI |
M0024535
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| NDFRT kind |
INGREDIENT_KIND
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| notation |
N0000006111
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| NUI |
N0000006111
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| prefLabel |
Didanosine [Chemical/Ingredient]
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| tui |
T114 T121
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| subClassOf |
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