loading...| Preferred Name |
Penicillamine |
|
| Synonyms |
.beta.,.beta.-Dimethylcysteine PENICILLAMINE D-Mercaptovaline Beta-thiovaline Alpha-amino-beta-methyl-beta-mercaptobutyric Acid Metalcaptase penicillamine Beta,Beta-dimethylcysteine 3-Mercapto-D-valine Penicillamine D-Penicillamine Atamir Cuprenil Cuprimine Cupripen Depamine Depen Distamine Kelatin Mercaptyl Pendramine Perdolat Sufortan Trolovol |
|
| Definitions |
A beta dimethyl analog of the amino acid cysteine. As a degradation product of penicillin antibiotics, penicillamine chelates with heavy metals and increases their urinary excretion. Possessing antineoplastic properties, penicillamine induces apoptosis by a p53-mediated mechanism and inhibits angiogenesis by chelating with copper, a cofactor for angiogenesis. (NCI04) |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C729 |
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| Accepted_Therapeutic_Use_For |
Wilsons disease; heavy metal intoxication; cystinuria; rheumatoid arthritis; primary biliary cirrhosis; Feltys syndrome; rheumatoid vasculitis |
|
| ALT_DEFINITION |
A drug that removes copper from the body and is used to treat diseases in which there is an excess of this metal. It is also being studied as a possible angiogenesis inhibitor in brain tumors. |
|
| CAS_Registry |
52-67-5 |
|
| CHEBI_ID |
CHEBI:7959 |
|
| Chemical_Formula |
C5H11NO2S |
|
| code |
C729 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
|
| Contributing_Source |
FDA GDC |
|
| DEFINITION |
A beta dimethyl analog of the amino acid cysteine. As a degradation product of penicillin antibiotics, penicillamine chelates with heavy metals and increases their urinary excretion. Possessing antineoplastic properties, penicillamine induces apoptosis by a p53-mediated mechanism and inhibits angiogenesis by chelating with copper, a cofactor for angiogenesis. (NCI04) |
|
| FDA_UNII_Code |
GNN1DV99GX |
|
| FULL_SYN |
.beta.,.beta.-Dimethylcysteine PENICILLAMINE D-Mercaptovaline Beta-thiovaline Alpha-amino-beta-methyl-beta-mercaptobutyric Acid Metalcaptase penicillamine Beta,Beta-dimethylcysteine 3-Mercapto-D-valine Penicillamine D-Penicillamine Atamir Cuprenil Cuprimine Cupripen Depamine Depen Distamine Kelatin Mercaptyl Pendramine Perdolat Sufortan Trolovol |
|
| Is_Value_For_GDC_Property | ||
| label |
Penicillamine |
|
| Legacy Concept Name |
Penicillamine |
|
| Maps_To |
Penicillamine |
|
| NCI_Drug_Dictionary_ID |
42546 |
|
| NSC Number |
81549 |
|
| PDQ_Closed_Trial_Search_ID |
42546 |
|
| PDQ_Open_Trial_Search_ID |
42546 |
|
| Preferred_Name |
Penicillamine |
|
| prefixIRI |
Thesaurus:C729 |
|
| Semantic_Type |
Amino Acid, Peptide, or Protein Pharmacologic Substance |
|
| UMLS_CUI |
C0030817 |
|
| subClassOf |