Preferred Name |
Omapatrilat |
|
Synonyms |
OMAPATRILAT Omapatrilat (4S,7S,10aS)-Octahydro-4-((S)-Alpha-Mercaptohydrocinnamamido)-5-Oxo-7H-Pyrido(2,1-B)(1,3)Thiazepine-7-Carboxylic Acid BMS-186716-01 Omapatrilate BMS-186716 Vanlev |
|
Definitions |
A vasopeptidase inhibitor with antihypertensive activity. Omapatrilat exerts its effect by inhibiting angiotensin converting enzyme (ACE) and neutral endopeptidase (NEP). ACE inhibition results in inhibition of the renin-angiotensin-aldosterone system thereby leading to the reduction of vasoconstriction. Inhibition of NEP leads to the inhibition of hydrolyzation of a number of endogenous vasoactive peptides, such as bradykinin and substance P and as NEP is the principal enzyme degrading natriuretic peptides, NEP inhibition also results in an increase in natriuretic peptidase circulation. Ultimately both effects result in blood vessel relaxation. |
|
ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1782 |
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CAS_Registry |
167305-00-2 |
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Chemical_Formula |
C19H24N2O4S2 |
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code |
C1782 |
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Concept_In_Subset | ||
Contributing_Source |
FDA |
|
DEFINITION |
A vasopeptidase inhibitor with antihypertensive activity. Omapatrilat exerts its effect by inhibiting angiotensin converting enzyme (ACE) and neutral endopeptidase (NEP). ACE inhibition results in inhibition of the renin-angiotensin-aldosterone system thereby leading to the reduction of vasoconstriction. Inhibition of NEP leads to the inhibition of hydrolyzation of a number of endogenous vasoactive peptides, such as bradykinin and substance P and as NEP is the principal enzyme degrading natriuretic peptides, NEP inhibition also results in an increase in natriuretic peptidase circulation. Ultimately both effects result in blood vessel relaxation. |
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FDA_UNII_Code |
36NLI90E7T |
|
FULL_SYN |
OMAPATRILAT Omapatrilat (4S,7S,10aS)-Octahydro-4-((S)-Alpha-Mercaptohydrocinnamamido)-5-Oxo-7H-Pyrido(2,1-B)(1,3)Thiazepine-7-Carboxylic Acid BMS-186716-01 Omapatrilate BMS-186716 Vanlev |
|
label |
Omapatrilat |
|
Legacy Concept Name |
Omapatrilat |
|
Preferred_Name |
Omapatrilat |
|
prefixIRI |
Thesaurus:C1782 |
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Semantic_Type |
Organic Chemical Pharmacologic Substance |
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UMLS_CUI |
C0663645 |
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subClassOf |