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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Preferred Name | Monobenzone | |
| Synonyms |
monobenzyl ether of hydroquinone Hydroquinone monobenzyl ether Monobenzone MONOBENZONE Monobenzyl ether hydroquinone Benoquin MBEH |
|
| Definitions |
A monobenzyl ether of hydroquinone with topical depigmentation activity. Although the exact mechanism of action of depigmentation is unknown, the metabolites of monobenzone appear to have a cytotoxic effect on melanocytes. Furthermore, the depigmentation effect might be mediated through the inhibition of tyrosinase, which is essential in the synthesis of melanin pigments, thereby causing permanent depigmentation of the skin. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C992 |
|
| Accepted_Therapeutic_Use_For |
Vitiligo
|
|
| CAS_Registry |
103-16-2
|
|
| CHEBI_ID |
CHEBI:34380
|
|
| Chemical_Formula |
C13H12O2
|
|
| code |
C992
|
|
| Concept_In_Subset | ||
| Contributing_Source |
FDA
|
|
| DEFINITION |
A monobenzyl ether of hydroquinone with topical depigmentation activity. Although the exact mechanism of action of depigmentation is unknown, the metabolites of monobenzone appear to have a cytotoxic effect on melanocytes. Furthermore, the depigmentation effect might be mediated through the inhibition of tyrosinase, which is essential in the synthesis of melanin pigments, thereby causing permanent depigmentation of the skin.
|
|
| FDA_UNII_Code |
9L2KA76MG5
|
|
| FULL_SYN |
monobenzyl ether of hydroquinone Hydroquinone monobenzyl ether Monobenzone MONOBENZONE Monobenzyl ether hydroquinone Benoquin MBEH
|
|
| label |
Monobenzone
|
|
| Legacy Concept Name |
Monobenzone
|
|
| NCI_Drug_Dictionary_ID |
39494
|
|
| NSC Number |
33918
|
|
| PDQ_Closed_Trial_Search_ID |
39494
|
|
| PDQ_Open_Trial_Search_ID |
39494
|
|
| Preferred_Name |
Monobenzone
|
|
| prefixIRI |
Thesaurus:C992
|
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance
|
|
| UMLS_CUI |
C0050962
|
|
| subClassOf |
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