loading...| Preferred Name |
Ixazomib |
|
| Synonyms |
{(1R)-1-[(2,5-dichlorobenzamido)acetamido]-3-methylbutyl}boronic Acid IXAZOMIB Ixazomib MLN-2238 MLN2238 |
|
| Definitions |
An active metabolite of MLN9708, a second generation, boron containing peptide proteasome inhibitor (PI) with potential antineoplastic activity. Ixazomib binds to and inhibits the 20S catalytic core of the proteasome, thereby blocking the targeted proteolysis normally performed by the proteasome, which results in an accumulation of unwanted or misfolded proteins; disruption of various cell signaling pathways may follow, resulting in the induction of apoptosis. Compared to first generation PIs, second generation PIs may have an improved pharmacokinetic profile with increased potency and less toxicity. Proteasomes are large protease complexes that degrade unneeded or damaged proteins that have been ubiquinated. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C97940 |
|
| CAS_Registry |
1072833-77-2 |
|
| Chemical_Formula |
C14H19BCl2N2O4 |
|
| code |
C97940 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
|
| Contributing_Source |
FDA GDC HemOnc |
|
| DEFINITION |
An active metabolite of MLN9708, a second generation, boron containing peptide proteasome inhibitor (PI) with potential antineoplastic activity. Ixazomib binds to and inhibits the 20S catalytic core of the proteasome, thereby blocking the targeted proteolysis normally performed by the proteasome, which results in an accumulation of unwanted or misfolded proteins; disruption of various cell signaling pathways may follow, resulting in the induction of apoptosis. Compared to first generation PIs, second generation PIs may have an improved pharmacokinetic profile with increased potency and less toxicity. Proteasomes are large protease complexes that degrade unneeded or damaged proteins that have been ubiquinated. |
|
| FDA_UNII_Code |
71050168A2 |
|
| FULL_SYN |
{(1R)-1-[(2,5-dichlorobenzamido)acetamido]-3-methylbutyl}boronic Acid IXAZOMIB Ixazomib MLN-2238 MLN2238 |
|
| Has_Salt_Form | ||
| Has_Target | ||
| Is_Value_For_GDC_Property | ||
| label |
Ixazomib |
|
| Maps_To |
Ixazomib |
|
| Preferred_Name |
Ixazomib |
|
| prefixIRI |
Thesaurus:C97940 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C3467949 |
|
| subClassOf |