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National Cancer Institute Thesaurus
| Preferred Name | Amantadine Sulfate | |
| Synonyms |
Amantadine Sulfate AMANTADINE SULFATE |
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| Definitions |
The sulfate salt of amantadine, a synthetic tricyclic amine with antiviral, antiparkinsonian, and antihyperalgesic activities. Amantadine appears to exert its antiviral effect against the influenza A virus by interfering with the function of the transmembrane domain of the viral M2 protein, thereby preventing the release of infectious viral nucleic acids into host cells; furthermore, this agent prevents virus assembly during virus replication. Amantadine exerts its antiparkinsonian effects by stimulating the release of dopamine from striatal dopaminergic nerve terminals and inhibiting its pre-synaptic reuptake. This agent may also exert some anticholinergic effect through inhibition of N-methyl-D-aspartic acid (NMDA) receptor-mediated stimulation of acetylcholine, resulting in antihyperalgesia. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C90781 |
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| CAS_Registry |
31377-23-8
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| Chemical_Formula |
2C10H17N.H2O4S
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| code |
C90781
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| Concept_In_Subset | ||
| Contributing_Source |
FDA
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| DEFINITION |
The sulfate salt of amantadine, a synthetic tricyclic amine with antiviral, antiparkinsonian, and antihyperalgesic activities. Amantadine appears to exert its antiviral effect against the influenza A virus by interfering with the function of the transmembrane domain of the viral M2 protein, thereby preventing the release of infectious viral nucleic acids into host cells; furthermore, this agent prevents virus assembly during virus replication. Amantadine exerts its antiparkinsonian effects by stimulating the release of dopamine from striatal dopaminergic nerve terminals and inhibiting its pre-synaptic reuptake. This agent may also exert some anticholinergic effect through inhibition of N-methyl-D-aspartic acid (NMDA) receptor-mediated stimulation of acetylcholine, resulting in antihyperalgesia.
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| FDA_UNII_Code |
9921T5P019
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| FULL_SYN |
Amantadine Sulfate AMANTADINE SULFATE
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| Has_Free_Acid_Or_Base_Form | ||
| label |
Amantadine Sulfate
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| Preferred_Name |
Amantadine Sulfate
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| prefixIRI |
Thesaurus:C90781
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| Semantic_Type |
Organic Chemical Pharmacologic Substance
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| UMLS_CUI |
C0002404
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| subClassOf |
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