loading...| Preferred Name | Trifluoperazine Hydrochloride | |
| Synonyms |
Trifluoperazine Dihydrochloride 10-(3-(4-Methyl-1-piperazinyl)propyl)-2-(trifluoromethyl)-10H-phenothiazine Dihydrochloride Jatroneural TRIFLUOPERAZINE HYDROCHLORIDE Trifluoperazine Hydrochloride Eskazine SKF 5019 Stelazine Terfluzine |
|
| Definitions |
The hydrochloride salt of trifluoperazine, a phenothiazine derivative and a dopamine, alpha-adrenergic, and anticholinergic antagonist with antipsychotic, anxiolytic, and antiemetic activities. Trifluoperazine blocks central dopamine receptors, which may prevent or mitigate delusions and hallucinations caused by an excess of dopamine; dopamine blockade in the chemoreceptor trigger zone (CTZ) may result in an antiemetic effect. This agent binds to central adrenergic receptors, which may result in anxiolytic effects. Trifluoperazine also functions as a calmodulin inhibitor, elevating cytosolic calcium. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C904 |
|
| CAS_Registry |
440-17-5 |
|
| CHEBI_ID |
CHEBI:9710 |
|
| Chemical_Formula |
C21H24F3N3S.2HCl |
|
| code |
C904 |
|
| Concept_In_Subset | ||
| Contributing_Source |
FDA |
|
| DEFINITION |
The hydrochloride salt of trifluoperazine, a phenothiazine derivative and a dopamine, alpha-adrenergic, and anticholinergic antagonist with antipsychotic, anxiolytic, and antiemetic activities. Trifluoperazine blocks central dopamine receptors, which may prevent or mitigate delusions and hallucinations caused by an excess of dopamine; dopamine blockade in the chemoreceptor trigger zone (CTZ) may result in an antiemetic effect. This agent binds to central adrenergic receptors, which may result in anxiolytic effects. Trifluoperazine also functions as a calmodulin inhibitor, elevating cytosolic calcium. |
|
| FDA_UNII_Code |
6P1Y2SNF5V |
|
| FULL_SYN |
Trifluoperazine Dihydrochloride 10-(3-(4-Methyl-1-piperazinyl)propyl)-2-(trifluoromethyl)-10H-phenothiazine Dihydrochloride Jatroneural TRIFLUOPERAZINE HYDROCHLORIDE Trifluoperazine Hydrochloride Eskazine SKF 5019 Stelazine Terfluzine |
|
| Has_Free_Acid_Or_Base_Form | ||
| label |
Trifluoperazine Hydrochloride |
|
| Legacy Concept Name |
Trifluoperazine |
|
| NCI_Drug_Dictionary_ID |
40446 |
|
| NSC Number |
17474 |
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| PDQ_Closed_Trial_Search_ID |
40446 |
|
| PDQ_Open_Trial_Search_ID |
40446 |
|
| Preferred_Name |
Trifluoperazine Hydrochloride |
|
| prefixIRI |
Thesaurus:C904 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0304381 |
|
| subClassOf |