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National Cancer Institute Thesaurus
| Preferred Name | Bedaquiline | |
| Synonyms |
Bedaquiline 1-(6-bromo-2-methoxy-quinolin-3-yl)-4-dimethylamino-2-(3-fluorophenyl)-1-phenyl-butan-2-ol 3-Quinolineethanol, 6-Bromo-Alpha-(2-(Dimethylamino)Ethyl)-2-Methoxy-Alpha-1-Naphthalenyl-Beta-Phenyl-, (Alpha-S,Beta-R)- BEDAQUILINE R207910 TMC207 |
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| Definitions |
An orally bioavailable diarylquinoline antimycobacterial agent, that can be used in the treatment of pulmonary multi-drug resistant tuberculosis (MDR-TB). Upon oral administration, bedaquiline specifically binds to subunit c of Mycobacterium tuberculosis (M. tuberculosis) adenosine 5'-triphosphate (ATP) synthase, thereby preventing ATP synthase activity. This inhibits ATP synthesis in M. tuberculosis, thereby blocking its energy metabolism and killing M. tuberculosis. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C87658 |
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| CAS_Registry |
843663-66-1
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| Chemical_Formula |
C32H31BrN2O2
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|
| code |
C87658
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|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 |
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| Contributing_Source |
CTRP FDA
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|
| DEFINITION |
An orally bioavailable diarylquinoline antimycobacterial agent, that can be used in the treatment of pulmonary multi-drug resistant tuberculosis (MDR-TB). Upon oral administration, bedaquiline specifically binds to subunit c of Mycobacterium tuberculosis (M. tuberculosis) adenosine 5'-triphosphate (ATP) synthase, thereby preventing ATP synthase activity. This inhibits ATP synthesis in M. tuberculosis, thereby blocking its energy metabolism and killing M. tuberculosis.
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|
| Display_Name |
Bedaquiline
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| FDA_UNII_Code |
78846I289Y
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| FULL_SYN |
Bedaquiline 1-(6-bromo-2-methoxy-quinolin-3-yl)-4-dimethylamino-2-(3-fluorophenyl)-1-phenyl-butan-2-ol 3-Quinolineethanol, 6-Bromo-Alpha-(2-(Dimethylamino)Ethyl)-2-Methoxy-Alpha-1-Naphthalenyl-Beta-Phenyl-, (Alpha-S,Beta-R)- BEDAQUILINE R207910 TMC207
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|
| label |
Bedaquiline
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| NCI_Drug_Dictionary_ID |
811246
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| Preferred_Name |
Bedaquiline
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| prefixIRI |
Thesaurus:C87658
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| Semantic_Type |
Pharmacologic Substance
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| UMLS_CUI |
C1664205
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| subClassOf |
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