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National Cancer Institute Thesaurus
| Preferred Name | Telavancin Hydrochloride | |
| Synonyms |
Telavancin Hydrochloride Vancomycin, N(Sup 3'')-(2-(Decylamino)Ethyl)-29-(((Phosphonomethyl)Amino)Methyl)-, Monohydrochloride TELAVANCIN HYDROCHLORIDE TD-6424 Vibativ |
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| Definitions |
The hydrochloride salt form of telavancin, a lipoglycopeptide and a semisynthetic derivative of vancomycin with antibacterial activity against gram-positive bacteria. Like vancomycin, telavancin binds tightly to the D-alanyl-D-alanine residue of cell wall precursors, thereby interfering with bacterial cell wall synthesis. In addition, the lipophilic moiety of telavancin may interact with the lipid bilayer in the bacterial cell membrane, thereby compromising the integrity of cell membrane and causing cell membrane depolarization. This novel mechanism of action may contribute to telavancin's rapid bactericidal activity and its improved activity over vancomycin against some antibiotic resistance gram-positive bacteria. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C87636 |
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| CAS_Registry |
560130-42-9
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| Chemical_Formula |
C80H106Cl2N11O27P.HCl
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| code |
C87636
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| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 |
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| Contributing_Source |
CTRP FDA
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|
| DEFINITION |
The hydrochloride salt form of telavancin, a lipoglycopeptide and a semisynthetic derivative of vancomycin with antibacterial activity against gram-positive bacteria. Like vancomycin, telavancin binds tightly to the D-alanyl-D-alanine residue of cell wall precursors, thereby interfering with bacterial cell wall synthesis. In addition, the lipophilic moiety of telavancin may interact with the lipid bilayer in the bacterial cell membrane, thereby compromising the integrity of cell membrane and causing cell membrane depolarization. This novel mechanism of action may contribute to telavancin's rapid bactericidal activity and its improved activity over vancomycin against some antibiotic resistance gram-positive bacteria.
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| Display_Name |
Telavancin Hydrochloride
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| FDA_UNII_Code |
0701472ZG0
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| FULL_SYN |
Telavancin Hydrochloride Vancomycin, N(Sup 3'')-(2-(Decylamino)Ethyl)-29-(((Phosphonomethyl)Amino)Methyl)-, Monohydrochloride TELAVANCIN HYDROCHLORIDE TD-6424 Vibativ
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| Has_Free_Acid_Or_Base_Form | ||
| label |
Telavancin Hydrochloride
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| NCI_Drug_Dictionary_ID |
698126
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| PDQ_Closed_Trial_Search_ID |
698126
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| PDQ_Open_Trial_Search_ID |
698126
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| Preferred_Name |
Telavancin Hydrochloride
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| prefixIRI |
Thesaurus:C87636
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| Semantic_Type |
Pharmacologic Substance
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| UMLS_CUI |
C2730005
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| subClassOf |
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