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National Cancer Institute Thesaurus
| Preferred Name | Thiotepa | |
| Synonyms |
Triethylene Thiophosphoramide Thiophosphamide N,N',N''-triethylenethiophosphoramide 1,1',1''-Phosphinothioylidynetrisaziridine 1,1',1''-Phosphinothioyldynetrisaziridine Triethylene thiophosphoramide Tris(1-aziridinyl)phosphine sulfide Oncotiotepa Thiophosphoamide Thiophosphoramide Thiofosfamide tris(1-aziridinyl)phosphine sulfide N,N', N''-Triethylenethiophosphoramide 1,1',1"-phosphinothioylidynetrisaziridine Triethylenethiophosphoramide triethylenethiophosphoramide Girostan STEPA TESPA THIOTEPA TIO TEF TSPA Tepadina Tespamin Tespamine Thio-Tepa Thiofozil Thioplex Thiotef Thiotepa Tifosyl Tio-tef WR 45312 thiotepa |
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| Definitions |
A polyfunctional, organophosphorus alkylating agent and a stable derivative of N,N',N''-triethylenephosphoramide (TEPA), with antineoplastic activity. Upon administration, thiotepa is converted into highly reactive ethylenimine groups, which covalently bind to nucleophilic groups in DNA and demonstrate a preference for the N7 position of guanine bases. This induces crosslinking of alkylated guanine bases in double-stranded DNA, interferes with both DNA replication and cell division, and results in both the induction of apoptosis and the inhibition of cell growth. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C875 |
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| Accepted_Therapeutic_Use_For |
Bladder cancer; Breast cancer; Ovarian cancer; Hodgkins lymphoma; Non-hodgkins lymphoma
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| ALT_DEFINITION |
An anticancer drug that belongs to the family of drugs called alkylating agents.
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|
| CAS_Registry |
52-24-4
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|
| Chemical_Formula |
C6H12N3PS
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|
| code |
C875
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| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173234 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C186328 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C186327 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C174019 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C186341 |
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| Contributing_Source |
CTRP FDA GDC HemOnc PCDC
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|
| DEFINITION |
A polyfunctional, organophosphorus alkylating agent and a stable derivative of N,N',N''-triethylenephosphoramide (TEPA), with antineoplastic activity. Upon administration, thiotepa is converted into highly reactive ethylenimine groups, which covalently bind to nucleophilic groups in DNA and demonstrate a preference for the N7 position of guanine bases. This induces crosslinking of alkylated guanine bases in double-stranded DNA, interferes with both DNA replication and cell division, and results in both the induction of apoptosis and the inhibition of cell growth.
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|
| Display_Name |
Thiotepa
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|
| FDA_UNII_Code |
905Z5W3GKH
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| FULL_SYN |
Triethylene Thiophosphoramide Thiophosphamide N,N',N''-triethylenethiophosphoramide 1,1',1''-Phosphinothioylidynetrisaziridine 1,1',1''-Phosphinothioyldynetrisaziridine Triethylene thiophosphoramide Tris(1-aziridinyl)phosphine sulfide Oncotiotepa Thiophosphoamide Thiophosphoramide Thiofosfamide tris(1-aziridinyl)phosphine sulfide N,N', N''-Triethylenethiophosphoramide 1,1',1"-phosphinothioylidynetrisaziridine Triethylenethiophosphoramide triethylenethiophosphoramide Girostan STEPA TESPA THIOTEPA TIO TEF TSPA Tepadina Tespamin Tespamine Thio-Tepa Thiofozil Thioplex Thiotef Thiotepa Tifosyl Tio-tef WR 45312 thiotepa
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| Is_PCDC_AML_Authorized_Value_For_Variable | ||
| Is_Value_For_GDC_Property | ||
| label |
Thiotepa
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| Legacy Concept Name |
Thiotepa
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|
| Maps_To |
Thiotepa
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| NCI_Drug_Dictionary_ID |
42933
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| NSC Number |
6396
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| PDQ_Closed_Trial_Search_ID |
42933
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| PDQ_Open_Trial_Search_ID |
42933
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|
| Preferred_Name |
Thiotepa
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|
| prefixIRI |
Thesaurus:C875
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|
| Semantic_Type |
Organic Chemical Pharmacologic Substance
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|
| UMLS_CUI |
C0039871
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| subClassOf |
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