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National Cancer Institute Thesaurus
| Preferred Name | Propicillin Potassium | |
| Synonyms |
(2S,5R,6R)-3,3-Dimethyl-7-Oxo-6-((1-Oxo-2-Phenoxybutyl)Amino)-4-Thia-1-Azabicyclo(3.2.0)Heptane-2-Carboxylic Acid Potassium Salt Alpha-Phenoxypropylpenicillin Potassium Salt Propicillin Potassium 6-(Alpha-Phenoxybutyramido)Penicillanic Acid Potassium Salt PROPICILLIN POTASSIUM |
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| Definitions |
The potassium salt form of propicillin, a semisynthetic acid-stable penicillin with antibacterial activity. Propicillin binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This interrupts bacterial cell wall synthesis and results in the weakening of the bacterial cell wall, eventually causing cell lysis. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C87371 |
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| CAS_Registry |
1245-44-9
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| CHEBI_ID |
CHEBI:32062
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| Chemical_Formula |
C18H21N2O5S.K
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| code |
C87371
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| Concept_In_Subset | ||
| Contributing_Source |
FDA
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| DEFINITION |
The potassium salt form of propicillin, a semisynthetic acid-stable penicillin with antibacterial activity. Propicillin binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This interrupts bacterial cell wall synthesis and results in the weakening of the bacterial cell wall, eventually causing cell lysis.
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| FDA_UNII_Code |
75RXW2P83Y
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| FULL_SYN |
(2S,5R,6R)-3,3-Dimethyl-7-Oxo-6-((1-Oxo-2-Phenoxybutyl)Amino)-4-Thia-1-Azabicyclo(3.2.0)Heptane-2-Carboxylic Acid Potassium Salt Alpha-Phenoxypropylpenicillin Potassium Salt Propicillin Potassium 6-(Alpha-Phenoxybutyramido)Penicillanic Acid Potassium Salt PROPICILLIN POTASSIUM
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|
| label |
Propicillin Potassium
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| Preferred_Name |
Propicillin Potassium
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| prefixIRI |
Thesaurus:C87371
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| Semantic_Type |
Pharmacologic Substance
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| UMLS_CUI |
C0771910
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| subClassOf |
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