loading...| Preferred Name |
Deflazacort |
|
| Synonyms |
DEFLAZACORT 5'H-Pregna-1,4-Dieno(17,16-d)Oxazole-3,20-Dione, 21-(Acetyloxy)-11-Hydroxy-2'-Methyl-, (11Beta,16Beta)- Deflazacort 11Beta,21-Dihydroxy-2'-Methyl-5'Beta-H-Pregna-1,4-Dieno(17,16-D)Oxazole-3,20-Dione 21-Acetate Emflaza MDL 458 |
|
| Definitions |
A synthetic glucocorticoid prodrug, with anti-inflammatory and immunomodulating properties. Upon administration, the active metabolite of deflazacort, 21-desacetyl deflazacort, binds to and activates tissue glucocorticoid receptors. This results in the inhibition of specific leukocyte functions and the inhibition of proinflammatory cytokine production. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C87230 |
|
| CAS_Registry |
14484-47-0 |
|
| Chemical_Formula |
C25H31NO6 |
|
| code |
C87230 |
|
| Concept_In_Subset | ||
| Contributing_Source |
FDA |
|
| DEFINITION |
A synthetic glucocorticoid prodrug, with anti-inflammatory and immunomodulating properties. Upon administration, the active metabolite of deflazacort, 21-desacetyl deflazacort, binds to and activates tissue glucocorticoid receptors. This results in the inhibition of specific leukocyte functions and the inhibition of proinflammatory cytokine production. |
|
| FDA_UNII_Code |
KR5YZ6AE4B |
|
| FULL_SYN |
DEFLAZACORT 5'H-Pregna-1,4-Dieno(17,16-d)Oxazole-3,20-Dione, 21-(Acetyloxy)-11-Hydroxy-2'-Methyl-, (11Beta,16Beta)- Deflazacort 11Beta,21-Dihydroxy-2'-Methyl-5'Beta-H-Pregna-1,4-Dieno(17,16-D)Oxazole-3,20-Dione 21-Acetate Emflaza MDL 458 |
|
| label |
Deflazacort |
|
| NCI_Drug_Dictionary_ID |
802842 |
|
| PDQ_Closed_Trial_Search_ID |
802842 |
|
| PDQ_Open_Trial_Search_ID |
802842 |
|
| Preferred_Name |
Deflazacort |
|
| prefixIRI |
Thesaurus:C87230 |
|
| Semantic_Type |
Pharmacologic Substance |
|
| UMLS_CUI |
C0057258 |
|
| subClassOf |